Search Results for: Dna

January 21, 2025January 21, 2025

Modifying non-coding regions of linear DNA vaccines to explore the interplay of expression and inflammation in immunogenicity.

Publication date: Dec 01, 2025 Open Access PDF Concepts Keywords Doggybone Animals Oligodeoxynucleotide COVID-19 Target COVID-19 Underperformed COVID-19 Vaccines Vaccine COVID-19 Vaccines CpG Female Humans Immunogenicity, Vaccine Inflammation inflammation influenza ... Read more

January 19, 2025January 19, 2025

Rapid Generation of Reverse Genetics Systems for Coronavirus Research and High-Throughput Antiviral Screening Using Gibson DNA Assembly.

Coronavirus Literature

Publication date: Jan 01, 2025 Coronaviruses (CoVs) pose a significant threat to human health, as demonstrated by the COVID-19 pandemic. The large size of the CoV genome (around 30 kb) represents ... Read more

January 18, 2025January 18, 2025

DNA repeat expansion drives Huntington’s development

Huntington's Disease News

Publication date: Jan 18, 2025 In a pair of studies of Huntingtons disease published this week, researchers report that this process, called somatic repeat expansion, is a key driver in ... Read more

January 16, 2025January 16, 2025

Circulating Tumor DNA in Conjunctival Melanoma: Landscape and Surveillance Value.

Melanoma Literature

Publication date: Feb 01, 2025 To evaluate the surveillance value of circulating tumor DNA (ctDNA) for detecting distant metastasis and indicating systemic therapeutic efficacy in conjunctival melanoma (CoM). Retrospective, observational ... Read more

January 11, 2025January 11, 2025

Msh2-Msh3 DNA-binding is not sufficient to promote trinucleotide repeat expansions in Saccharomyces cerevisiae.

Huntington's Disease Literature

Publication date: Jan 10, 2025 Mismatch repair (MMR) is a highly conserved DNA repair pathway that recognizes mispairs that occur spontaneously during DNA replication and coordinates their repair. In Saccharomyces ... Read more

January 11, 2025January 11, 2025

Epigenome-wide analysis reveals novel DNA methylation signatures significantly associated with the infant pupillary light reflex, a candidate intermediate phenotype for autism.

Autism News

Publication date: Jan 09, 2025 Autism is a highly heterogeneous neurodevelopmental condition, currently diagnosed based on behavioural characteristics. Candidate early intermediate phenotypes, such as the Pupillary Light Reflex (PLR), a ... Read more

January 10, 2025January 10, 2025

Biological Amyloids Chemically Damage DNA.

Parkinson's Disease Literature

Publication date: Jan 09, 2025 Amyloid fibrils are protein polymers noncovalently assembled through β-strands arranged in a cross-β structure. Biological amyloids were considered chemically inert until we and others recently ... Read more

January 10, 2025January 10, 2025

Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA.

Coronavirus Literature

Publication date: Nov 30, 2024 The nucleocapsid (N) protein is one of the four structural proteins in SARS-CoV-2, playing key roles in viral assembly, immune evasion, and stability. One of ... Read more

January 10, 2025January 10, 2025

Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA.

Coronavirus Literature

January 10, 2025January 10, 2025

Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA.

Coronavirus Literature