Publication date: Dec 06, 2019 Antonini, A. New routes of dopaminergic drug delivery in patients with Parkinson’s disease. 23265. 2019 Lancet Neurol. Concepts Keywords Drug addiction Drug delivery The Lancet ... Read more

Publication date: Dec 09, 2019 Parkinson’s disease (PD) results from the degeneration of the nervous tissue brought about by ecological and hereditary components which affects nerve cells in the brain. ... Read more

Publication date: Dec 08, 2019 To compare the efficacy of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) on reducing levodopa-induced dyskinesia (LID) in Parkinson’s disease, ... Read more

Publication date: Dec 06, 2019 Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer’s disease, Parkinson’s disease (PD) and sepsis. Despite microglial cells being the central ... Read more

Publication date: Dec 05, 2019 Metabolic dysfunction and neuroinflammation are increasingly implicated in Parkinson’s disease (PD). The pentose phosphate pathway (PPP, a metabolic pathway parallel to glycolysis) converts glucose-6-phosphate into ... Read more

Publication date: Dec 05, 2019 Using midbrain cultures, we previously demonstrated that the noble gas xenon is robustly protective for dopamine (DA) neurons exposed to L-trans-pyrrolidine-2,4-dicarboxylate (PDC), an inhibitor of ... Read more

Publication date: Dec 04, 2019 Dopamine loss beyond the mesostriatal system might be relevant in pathogenic mechanisms and some clinical manifestations in PD. The primate thalamus is densely and heterogeneously ... Read more

Publication date: Mar 15, 2019 Background and Aims: Pathological high amplitude of beta oscillations is thought as the underlying mechanism of motor symptoms in Parkinson’s disease (PD), in particular with ... Read more

Publication date: Apr 23, 2019 The Parkinson’s Disease Composite Scale (PDCS) is a recently developed easy-to-use tool enabling a timely but comprehensive assessment of Parkinson’s disease (PD)-related symptoms. Although the ... Read more

Publication date: Aug 20, 2019 A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A ... Read more