Publication date: Jul 02, 2020 To investigate whether the patterns of striatal dopamine depletion on dopamine transporter (DAT) scans could provide information on the long-term prognosis in Parkinson disease (PD). ... Read more

Publication date: Jul 03, 2020 Loss of nigrostriatal dopamine (DA) in Parkinson’s disease results in over-activation/bursting of the subthalamic nucleus (STN). The STN projects to the substantia nigra (SN) pars ... Read more

Publication date: Jul 03, 2020 Parkinson’s disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol ... Read more

Publication date: Jun 30, 2020 While the etiology of non-familial Parkinson’s disease (PD) remains unclear, there is evidence that increased levels of tissue iron may be a contributing factor. Moreover, ... Read more

Publication date: Jun 30, 2020 Chronic levodopa treatment in Parkinson’s disease (PD) may promote undesirable motor and non-motor fluctuations. Compared to chronic oral levodopa treatment, continuous infusion of levodopa/carbidopa intestinal ... Read more

Publication date: May 21, 2020 In patients with Parkinson’s disease (PD), pulsatile dopaminergic stimulation may be a primary cause of levodopa-induced dyskinesia (LID). We aimed to investigate the correlation between ... Read more

Publication date: Jun 29, 2020 Concepts Keywords Dopamine Branches of biology Metabolite Biomarkers Parkinson Clinical medicine Medicine Dopamine Semantics Type Source Name drug DRUGBANK Dopamine disease MESH Parkinson Disease pathway ... Read more

Publication date: Jun 29, 2020 To investigate S-adenosyl-methyonine (SAM) effects on PC12 cells viability and neuritogenesis treated with MPP+ (1-methyl-4-phenylpyridinium). PC12 cell viability test (MTT assay) in DMEM medium with ... Read more

Publication date: Jun 29, 2020 Concepts Keywords Dopamine Jama Metabolite Life sciences Parkinson Branches of biology Biomarkers Semantics Type Source Name drug DRUGBANK Dopamine disease MESH Parkinson Disease pathway KEGG ... Read more

Publication date: Jun 27, 2020 Dopaminergic deficiency in Parkinson’s disease (PD) has been associated with underactivation of the supplementary motor area and a reduction of voluntary actions. In these patients, ... Read more