Search Results for: Dopamine

January 17, 2020January 17, 2020

Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson’s Disease Discovered Using Isogenic Human Dopaminergic Neurons.

Publication date: Jan 14, 2020 Parkinson’s disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown ... Read more

January 17, 2020January 17, 2020

Thioredoxin-Interacting Protein (TXNIP) Regulates Parkin/PINK1-mediated Mitophagy in Dopaminergic Neurons Under High-glucose Conditions: Implications for Molecular Links Between Parkinson’s Disease and Diabetes.

Parkinson's Disease Literature

Publication date: Jan 14, 2020 Patients with diabetes mellitus have a higher risk of developing Parkinson’s disease (PD). However, the molecular links between PD and diabetes remain unclear. In this ... Read more

January 14, 2020

Up-regulation of microRNA-375 ameliorates the damage of dopaminergic neurons, reduces oxidative stress and inflammation in Parkinson’s disease by inhibiting SP1.

Parkinson's Disease Literature

Publication date: Jan 11, 2020 This study is conducted to investigate the protective role of elevated microRNA-375 (miR-375) in dopaminergic neurons in Parkinson’s disease through down-regulating transcription factor specificity protein ... Read more

January 9, 2020

Melatonin/polydopamine nanostructures for collective neuroprotection-based Parkinson’s disease therapy.

Parkinson's Disease Literature

Publication date: Jan 08, 2020 Parkinson’s disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra and localized deposition of cytoplasmic fibrillary inclusions as Lewy bodies ... Read more

December 17, 2019December 17, 2019

Nilotinib appears safe in Parkinson’s trial; drug thought to allow dopamine replenishment

Parkinson's Disease News

Publication date: Dec 16, 2019 Finally, they say nilotinib, a tyrosine kinase inhibitor, potentially halts motor and non-motor decline. Concepts Keywords Brain Tyrosine kinase inhibitor Clinical Trial Amphetamine Dopamine Dopamine ... Read more

November 2, 2019November 2, 2019

Cytosolic non-vesicular dopamine accumulation as the predominant mechanism for developing non-DOPA responsive parkinsonism in late-stage Huntington disease.

Huntington's Disease Literature

Publication date: Nov 01, 2019 Disturbances in motor movement can have similar clinical presentations, albeit having different pathways and temporal onset. Hypokinetic movements present with rigidity, resting tremors, postural instability ... Read more

September 4, 2019September 4, 2019

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers.

Melanoma Literature

Publication date: Sep 02, 2019 In preclinical studies serotonin stimulates and dopamine inhibits tumour growth and angiogenesis. Information regarding serotonin and dopamine receptor (5-HTR and DRD) expression in human cancers ... Read more

July 16, 2019July 16, 2019

Dysfunctional striatal dopamine signaling in Huntington’s disease.

Huntington's Disease Literature

Publication date: Jul 15, 2019 Dopamine signaling in the striatum is critical for a variety of behaviors including movement, behavioral flexibility, response to reward and many forms of learning. Alterations ... Read more

July 1, 2019July 1, 2019

Dopamine DR antagonist VK4-116 attenuates oxycodone self-administration and reinstatement without compromising its antinociceptive effects.

Opioids Literature

Publication date: Jul 01, 2019 Prescription opioids such as oxycodone are highly effective analgesics for clinical pain management, but their misuse and abuse have led to the current opioid epidemic ... Read more

June 19, 2019June 19, 2019

Intranasal Administration of Mesenchymal Stem Cells Ameliorates the Abnormal Dopamine Transmission System and Inflammatory Reaction in the R6/2 Mouse Model of Huntington Disease.

Huntington's Disease Literature

Publication date: Jun 15, 2019 Intrastriatal administration of mesenchymal stem cells (MSCs) has shown beneficial effects in rodent models of Huntington disease (HD). However, the invasive nature of surgical procedure ... Read more