Search Results for: Drug

January 18, 2025January 18, 2025

Optimization of a micro-scale air-liquid-interface model of human proximal airway epithelium for moderate throughput drug screening for SARS-CoV-2.

Publication date: Jan 16, 2025 Many respiratory viruses attack the airway epithelium and cause a wide spectrum of diseases for which we have limited therapies. To date, a few primary ... Read more

January 18, 2025January 18, 2025

In-silico screening and analysis of missense SNPs in human CYP3A4/5 affecting drug-enzyme interactions of FDA-approved COVID-19 antiviral drugs.

Coronavirus Literature

Publication date: Jan 16, 2025 Single nucleotide polymorphisms (SNPs) represent the prevailing form of genetic variations observed in the human population. Such variations could alter the encoded enzymes’ activities. CYP3A4/5 ... Read more

January 18, 2025January 18, 2025

Genetic analyses identify brain functional networks associated with the risk of Parkinson’s disease and drug-induced parkinsonism.

Parkinson's Disease Literature

Publication date: Jan 16, 2025 Brain functional networks are associated with parkinsonism in observational studies. However, the causal effects between brain functional networks and parkinsonism remain unclear. We aimed to ... Read more

January 18, 2025January 18, 2025

Network-Based Drug Optimization toward the Treatment of Parkinson’s Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation.

Parkinson's Disease Literature

Publication date: Jan 16, 2025 Parkinson’s disease (PD), the second most common neurodegenerative disorder, affects around 10 million people worldwide. It is a multifactorial disease marked by dopaminergic neuron loss ... Read more

January 18, 2025January 18, 2025

Targeted sputum sequencing for rapid and broad drug resistance of Mycobacterium tuberculosis.

Tuberculosis Literature

Publication date: Jan 16, 2025 Rapid detection of drug resistance in Mycobacterium tuberculosis (Mtb) from clinical samples facilitates the timely provision of optimal treatment regimens for tuberculosis (TB) patients. In ... Read more

January 18, 2025January 18, 2025

Antibiotic treatment for drug-resistant tuberculosis found to be safe and effective in clinical trial

Tuberculosis News

Publication date: Jan 18, 2025 The trial findings were combined with a second trial, TB-CHAMP, that took place in South Africa and involved the same treatment in children. Jointly, they ... Read more

January 17, 2025January 17, 2025

Drug-resistant tuberculosis is an important challenge in long COVID patients.

Coronavirus Literature

Publication date: Jan 14, 2025 Concepts Keywords Antimicrob Antimicrob Covid Covid Drug Drug Long Glob Tuberculosis Important Long Patients Resist Resistant Tuberculosis Semantics Type Source Name disease MESH Drug-resistant tuberculosis ... Read more

January 17, 2025January 17, 2025

Synthesis, biological evaluation and molecular docking studies of flavonol-3-O-β-D-glycoside as a potential inhibitor of SARS-CoV-2 main protease (3CLpro) in drug development for COVID-19.

Coronavirus Literature

Publication date: Jan 14, 2025 The COVID-19 pandemic began in March 2020 and has affected many countries and infected over a million people. It has had a serious impact on ... Read more

January 17, 2025January 17, 2025

Individualized Spectral Features in First-episode and Drug-naïve Major Depressive Disorder: Insights from Periodic and Aperiodic EEG Analysis.

Major Depressive Disorder Literature

Publication date: Jan 07, 2025 The detection of abnormal brain activity plays an important role in the early diagnosis and treatment of major depressive disorder (MDD). Recent studies have shown ... Read more

January 17, 2025January 17, 2025

Geospatial mapping of drug-resistant tuberculosis prevalence in Africa at national and sub-national levels.

Tuberculosis Literature

Publication date: Jan 07, 2025 To map subnational and local prevalence of drug-resistant tuberculosis (DR-TB) across Africa. We assembled a geolocated dataset from 173 sources across 31 African countries, comprising ... Read more