Search Results for: ERBB2

August 11, 2018August 11, 2018

Rates of ERBB2 Alterations Across Melanoma Subtypes and a Complete Response to Trastuzumab Emtansine in an ERBB2-amplified Acral Melanoma.

Melanoma Literature

Publication date: Aug 09, 2018 Patients with BRAF V600-wild type melanoma whose tumors progress on checkpoint inhibition currently have limited therapeutic options, and additional rational treatment targets are needed. ERBB2 ... Read more

June 27, 2018June 27, 2018

Targeting ERBB2 mutations in solid tumors: biological and clinical implications.

Melanoma Literature

Publication date: Jun 25, 2018 Preclinical data have shown that ERBB2 activating mutations are responsive to HER2 tyrosine kinase inhibitors. The aim of this study is to characterize the landscape ... Read more

November 16, 2019November 16, 2019

Real-time health monitoring through urine metabolomics.

Precision Medicine Literature

Publication date: Jun 25, 2019 Current healthcare practices are reactive and based on limited physiological information collected months or years apart. By enabling patients and healthy consumers access to continuous ... Read more

November 15, 2019November 15, 2019

System-based approaches as prognostic tools for glioblastoma.

Precision Medicine Literature

Publication date: Nov 12, 2019 The evasion of apoptosis is a hallmark of cancer. Understanding this process holistically and overcoming apoptosis resistance is a goal of many research teams in ... Read more

November 15, 2019November 15, 2019

The translational network for metabolic disease – from protein interaction to disease co-occurrence.

Precision Medicine Literature

Publication date: Nov 13, 2019 The recent advances in human disease network have provided insights into establishing the relationships between the genotypes and phenotypes of diseases. In spite of the ... Read more

November 15, 2019November 15, 2019

Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.

Melanoma Literature

Publication date: Nov 15, 2019 Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or ... Read more

November 9, 2019November 9, 2019

Primary diffuse meningeal melanomatosis – a rare form of meningeal melanoma: case report.

Melanoma Literature

Publication date: Nov 05, 2019 Meningeal melanomatosis is a rare type of central nervous system neoplasm (with incidence ranging between 3 and 5%) that develops in the course of malignant ... Read more

November 8, 2019November 8, 2019

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo.

Precision Medicine Literature

Publication date: Nov 06, 2019 Integrative analyses that summarize and link molecular data to treatment sensitivity are crucial to capture the biological complexity which is essential to further precision medicine. ... Read more

November 3, 2019November 3, 2019

Keynote: The Algorithm for Precision Medicine

Precision Medicine Media

Publication date: Nov 02, 2019 Concepts Keywords Accessibility Prototype tool Acid Reflux Side mining literature Alan Turing Lot national processing Algorithm Social media data Alphabet Fund tool Amino Acid Simulations ... Read more

November 2, 2019November 2, 2019

Prediction and Analysis of Skin Cancer Progression using Genomics Profiles of Patients.

Melanoma Literature

Publication date: Oct 31, 2019 The metastatic Skin Cutaneous Melanoma (SKCM) has been associated with diminished survival rates and high mortality rates worldwide. Thus, segregating metastatic melanoma from the primary ... Read more