Search Results for: Efferent

November 8, 2019November 8, 2019

Lack of mutant huntingtin in cortical efferents improves behavioral inflexibility and corticostriatal dynamics in Huntington’s disease mice.

Publication date: Nov 06, 2019 Abnormal communication between cerebral cortex and striatum plays a major role in the motor symptoms of Huntington’s disease (HD), a neurodegenerative disorder caused by a ... Read more

November 26, 2019November 26, 2019

Cortical Network Dynamics Is Altered in Mouse Models of Huntington’s Disease.

Huntington's Disease Literature

Publication date: Nov 25, 2019 Huntington’s disease (HD) is a neurodegenerative disorder characterized by involuntary movements, cognitive deficits, and psychiatric disturbances. Although evidence indicates that projections from motor cortical areas ... Read more

November 10, 2019November 10, 2019

Confidential genetic testing and electronic health records: A survey of current practices among Huntington disease testing centers.

Huntington's Disease Literature

Publication date: Nov 07, 2019 Clinical care teams providing presymptomatic genetic testing often employ advanced confidentiality practices for documentation and result storage. However, patient requests for increased confidentiality may be ... Read more

June 11, 2019June 11, 2019

Superconditioning TMS for examining upper motor neuron function in MND.

Multiple Sclerosis Literature

Publication date: Jun 07, 2019 We used transcranial magnetic stimulation (TMS) of motor cortex, including a novel four-pulse superconditioning (TMSsc) paradigm, in repeated examinations of motor-evoked potentials (MEPs) in eight ... Read more

June 11, 2019June 11, 2019

Joint assessment of brain and spinal cord motor tract damage in patients with early RRMS: predominant impact of spinal cord lesions on motor function.

Multiple Sclerosis Literature

Publication date: Jun 07, 2019 In patients with MS, the effect of structural damage to the corticospinal tract (CST) has been separately evaluated in the brain and spinal cord (SC), ... Read more

June 7, 2019June 7, 2019

For Massachusetts Eye and Ear Special Issue: Updates on Therapies for Multiple Sclerosis for the Ophthalmologist.

Multiple Sclerosis Literature

Publication date: Jun 03, 2019 In the past decade, the available disease-modifying therapies for multiple sclerosis have broadened significantly, providing physicians and patients with multiple options with different mechanisms of ... Read more

March 8, 2019March 8, 2019

Cancer and motor neuron disease-causal or coincidental? Two contrasting cases.

Multiple Sclerosis Literature

Publication date: Mar 06, 2019 Motor neuron disease (MND) can occur in patients with cancer, but there is minimal evidence that this is more than by chance. We contrast two ... Read more

March 3, 2019March 3, 2019

Targeting the Sigma-1 Receptor via Pridopidine Ameliorates Central Features of ALS Pathology in a SOD1 Model.

Huntington's Disease Literature

Publication date: Mar 01, 2019 Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease affecting both the upper and lower motor neurons (MNs), with no effective treatment currently available. Early ... Read more

February 3, 2019February 3, 2019

Aluminum in Neurological and Neurodegenerative Disease.

Multiple Sclerosis Literature

Publication date: Jan 31, 2019 With continuing cooperation from 18 domestic and international brain banks over the last 36 years, we have analyzed the aluminum content of the temporal lobe ... Read more

November 23, 2018November 23, 2018

Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis.

Multiple Sclerosis Literature

Publication date: Nov 21, 2018 Efferent visual dysfunction in children could lead to impaired quality of life at home and school. Eye-tracking can detect subtle efferent dysfunction missed on bedside ... Read more