Search Results for: Enhancers

October 23, 2019October 23, 2019

Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer.

Melanoma Literature

Publication date: Oct 21, 2019 Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to ... Read more

October 10, 2019October 10, 2019

Lopinavir Loaded Spray Dried Liposomes with Penetration Enhancers for Cytotoxic Activity.

Melanoma Literature

Publication date: Oct 08, 2019 HIV protease inhibitors (HIV-PI) are the drugs utilized for the treatment of HIV. However, its effectiveness is limited due to lack of bioavailability and need ... Read more

May 10, 2019May 10, 2019

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells.

Multiple Sclerosis Literature

Publication date: May 08, 2019 Several autoimmune diseases including multiple sclerosis (MS) cause increased transcription of endogenous retroviruses (HERVs) normally repressed by heterochromatin. In parallel, HERV-derived sequences were reported to ... Read more

January 24, 2019January 24, 2019

Transcriptionally induced enhancers in the macrophage immune response to Mycobacterium tuberculosis infection.

Tuberculosis Literature

Publication date: Jan 22, 2019 Tuberculosis is a life-threatening infectious disease caused by Mycobacterium tuberculosis (M.tb). M.tb subverts host immune responses to build a favourable niche and survive inside of ... Read more

November 23, 2018November 23, 2018

Discovery of Novel Enhancers of Isoniazid Toxicity in Mycobacterium tuberculosis.

Tuberculosis Literature

Publication date: Apr 04, 2018 The number of effective first-line antibiotics for the treatment of Mycobacterium tuberculosis infection is strongly limited to a few drugs. Due to emerging resistance against ... Read more

February 8, 2018February 8, 2018

High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.

Melanoma Literature

Publication date: Feb 02, 2018 Cutaneous melanoma is an aggressive tumor which accounts for most of the skin cancer deaths. Among the physiological barriers against therapeutic success is a strong ... Read more

November 26, 2019November 26, 2019

Webinar: “New Treatments in Testing to Slow or Stop Parkinson’s” November 2019

Parkinson's Disease Media

Publication date: Nov 25, 2019 Our panelists discuss the latest trials of therapies that may slow or stop Parkinson’s disease progression. Learn more about our webinar series at www.michaeljfox.org/webinars. Concepts ... Read more

November 22, 2019November 22, 2019

Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma.

Melanoma Literature

Publication date: Nov 20, 2019 The T cell immunoglobulin and mucin-domain containing-3 receptor TIM-3 (also known as hepatitis A virus cellular receptor 2, encoded by HAVCR2) and its ligand galectin ... Read more

November 15, 2019November 15, 2019

Chromatin accessibility and transcription dynamics during in vitro astrocyte differentiation of Huntington’s Disease Monkey pluripotent stem cells.

Huntington's Disease Literature

Publication date: Nov 13, 2019 Huntington’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear ... Read more

November 8, 2019November 8, 2019

The sirtuin 6: An overture in skin cancer.

Melanoma Literature

Publication date: Nov 07, 2019 In the recent past, the sirtuins have been under intense investigation for their roles in biology and disease, including cancer. The sirtuin SIRT6 is comparatively ... Read more