Search Results for: Enhancers

February 28, 2020February 28, 2020

Cognitive Enhancers in Depression: Research Review

Publication date: Feb 27, 2020 In this podcast episode, we review the research on cognitive enhancement agents in depression. 00:00 Welcome 00:57 Quick Takes with Dr. Jim Phelps 01:38 Vortioxetine ... Read more

June 28, 2020June 28, 2020

An Activity-Mediated Transition in Transcription in Early Postnatal Neurons.

Autism Literature

Publication date: Jun 24, 2020 The maturation of the mammalian brain occurs after birth, and this stage of neuronal development is frequently impaired in neurological disorders, such as autism and ... Read more

June 21, 2020June 21, 2020

Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy.

Coronavirus Literature

Publication date: Jun 10, 2020 In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against ... Read more

June 7, 2020June 7, 2020

Mitochondrial and Redox-Based Therapeutic Strategies in Huntington’s Disease.

Huntington's Disease Literature

Publication date: Jun 04, 2020 Significance: The molecular processes that determine Huntington’s disease (HD) pathogenesis are not yet fully understood, and until now no effective neuroprotective therapeutic strategies have been ... Read more

June 4, 2020June 4, 2020

Repurposed prophylaxis strategies for COVID-19: a systematic review

Coronavirus News

Publication date: Jun 02, 2020 Introduction Efficient therapeutic strategies are needed to counter the COVID-19 pandemic, caused by the SARS- CoV-2 virus. In a context where specific vaccines are not ... Read more

May 28, 2020May 28, 2020

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression.

Autism Literature

Publication date: May 25, 2020 Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-term chromatin remodeling around secondary response genes (SRGs). Here, we use high-resolution chromosome-conformation-capture carbon-copy ... Read more

May 21, 2020May 21, 2020

Genome-wide landscape of RNA-binding protein dysregulation reveals a major impact on psychiatric disorder risk

Major Depressive Disorder News

Publication date: May 19, 2020 Despite the strong genetic basis of psychiatric disorders, the molecular origins of these diseases are still largely unmapped. RNA-binding proteins (RBPs) are responsible for most ... Read more

May 18, 2020May 18, 2020

Evidence for enhancer noncoding RNAs (enhancer-ncRNAs) with gene regulatory functions relevant to neurodevelopmental disorders

Major Depressive Disorder News

Publication date: May 16, 2020 Noncoding RNAs (ncRNAs) comprise a significant proportion of the mammalian genome, but their biological significance in neurodevelopment and in diseases is poorly understood. In this ... Read more

March 2, 2020March 2, 2020

The Story of Prozac: A Landmark Drug in Psychiatry

Major Depressive Disorder News

Publication date: Mar 02, 2020 In the early 1970s, the pharmaceutical company Eli Lilly began to investigate the possibility of developing an antidepressant drug that avoided the potential cardiovascular risks ... Read more

February 6, 2020February 6, 2020

Genome-wide characterization of 5-hydoxymethylcytosine in melanoma reveals major differences with nevus.

Melanoma Literature

Publication date: Feb 03, 2020 Melanoma demonstrates altered patterns of DNA methylation that are associated with genetic instability and transcriptional repression of numerous genes. Active DNA demethylation is mediated by ... Read more