Search Results for: Flunarizine

February 8, 2025February 8, 2025

Outcome of Drug-Induced Parkinsonism in the Elderly: A Permanent Nonprogressive Parkinsonian Syndrome May Occur Following Discontinuation of Cinnarizine and Flunarizine.

Publication date: Mar 01, 2025 Parkinsonism induced by dopamine receptor antagonists, traditionally considered completely reversible following offending drug withdrawal, may unmask a degenerative parkinsonism in the patients with an underlying ... Read more

March 24, 2025March 24, 2025

Plasma gangliosides correlate with disease stages and symptom severity in Huntington disease carriers

Huntington's Disease News

Publication date: Mar 22, 2025 Background. Gangliosides – glycosphingolipids that modulate cell signaling and neuronal functions – are decreased in Huntington disease (HD) models and the brain of patients. Restoring ... Read more

March 23, 2025March 23, 2025

A novel approach to forecasting reproduction numbers of spatiotemporal stochastic epidemic spread using a PDE-based model and real-time infection data.

Coronavirus Literature

Publication date: Mar 21, 2025 The COVID-19 pandemic highlighted the need for improved epidemic spread forecasting, a critical precursor for developing optimal control measures for spread mitigation. Well-recognized shortcomings in ... Read more

March 23, 2025March 23, 2025

A Survey on Knowledge Graph Embedding: Approaches, Applications and Benchmarks

Dr. Richard A. Blevins News, Informatics News

Publication date: Mar 23, 2025 Traditional KG embedding models rely solely on the triplet structure to learn embeddings, but DKRL extends this by embedding the rich textual information found in ... Read more

March 22, 2025March 22, 2025

Endogenous viral elements constitute a complementary source of antigens for personalized cancer vaccines.

Melanoma Literature

Publication date: Mar 20, 2025 Personalized cancer vaccines (PCVs) largely leverage neoantigens arising from somatic mutations, limiting their application to patients with relatively high tumor mutational burden (TMB). This underscores ... Read more

March 22, 2025March 22, 2025

A reciprocal relationship between markers of genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.

Parkinson's Disease Literature

Publication date: Mar 20, 2025 DNA damage and DNA damage repair (DDR) dysfunction are insults with broad implications for cellular physiology and have been implicated in various neurodegenerative diseases. Alpha-synuclein ... Read more

March 22, 2025March 22, 2025

Differential large-scale network functional connectivity in cocaine-use disorder associates with drug-use outcomes.

Autism Literature

Publication date: Mar 20, 2025 Cocaine-use disorder (CUD) affects both structure and function of the brain. A triple network model of large-scale brain networks has been useful for identifying aberrant ... Read more

March 22, 2025March 22, 2025

Longitudinal analysis of immune responses to SARS-CoV-2 recombinant vaccine S-268019-b in phase 1/2 prime-boost study.

Coronavirus Literature

Publication date: Dec 23, 2024 The durability of vaccine-induced immune memory to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for preventing infection, especially severe disease. This follow-up report ... Read more

March 22, 2025March 22, 2025

Longitudinal analysis of immune responses to SARS-CoV-2 recombinant vaccine S-268019-b in phase 1/2 prime-boost study.

Coronavirus Literature

March 22, 2025March 22, 2025

Predicting coronavirus disease 2019 severity using explainable artificial intelligence techniques.

Coronavirus Literature

Publication date: Mar 19, 2025 Predictive models for determining coronavirus disease 2019 (COVID-19) severity have been established; however, the complexity of the interactions among factors limits the use of conventional ... Read more