Search Results for: Gene

March 21, 2019March 21, 2019

Neurogenetics of Huntington’s disease onset

Publication date: Mar 20, 2019 Lesley Jones, PhD, of Cardiff University, Cardiff, UK, discusses the neurogenetics of Huntington’s disease progression. This interview took place at the Alzheimer’s Research UK (ARUK) ... Read more

March 21, 2019March 21, 2019

(CAG) loci as genetic modifiers of age at onset in patients with spinocerebellar ataxia type 1 from mainland China.

Parkinson's Disease Literature

Publication date: Mar 19, 2019 The expanded repeat length in ATXN1 negatively correlates with age at onset (AAO) of SCA1 but can explain only part of it, indicating that other ... Read more

March 21, 2019March 21, 2019

Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Feb 12, 2019 Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson’s disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism ... Read more

March 20, 2019March 20, 2019

Circulating driver gene mutations: what is the impact on melanoma patients’ management?

Melanoma Literature

Publication date: Mar 18, 2019 Palmieri, G. Circulating driver gene mutations: what is the impact on melanoma patients’ management? 22023. 2019 Ann Oncol. Concepts Keywords Melanoma Medicine RTT Cancer Melanoma ... Read more

March 20, 2019March 20, 2019

Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway.

Melanoma Literature

Publication date: Mar 18, 2019 F-box proteins, a type of substrate-recognition complexes consisting of SKP1-cullin 1-F-box protein (SCF) E3 ligase, can critically affect many cellular processes because of the ubiquitylation ... Read more

March 20, 2019March 20, 2019

Clinically relevant concentrations of lidocaine inhibit tumor angiogenesis through suppressing VEGF/VEGFR2 signaling.

Melanoma Literature

Publication date: Mar 18, 2019 Angiogenesis, the formation of blood vessel, is required for invasive tumor growth and metastasis. In this study, the effects of lidocaine, an amide-link local anesthetic, ... Read more

March 20, 2019March 20, 2019

Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.

Melanoma Literature

Publication date: Mar 18, 2019 Melanoma is the deadliest form of skin cancer and one of the most aggressive cancers. ZFAS1 is a newly identified lncRNA, playing an oncogenic role ... Read more

March 20, 2019March 20, 2019

De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes.

Multiple Sclerosis Literature

Publication date: Mar 18, 2019 Recent studies have demonstrated genetic differences between monozygotic (MZ) twins. To test the hypothesis that early post-twinning mutational events associate with phenotypic discordance, we investigated ... Read more

March 20, 2019March 20, 2019

Personalized medicine in functional gastrointestinal disorders: Understanding pathogenesis to increase diagnostic and treatment efficacy.

Precision Medicine Literature

Publication date: Mar 14, 2019 There is overwhelming evidence that functional gastrointestinal disorders (FGIDs) are associated with specific mechanisms that constitute important targets for personalized treatment. There are specific mechanisms ... Read more

March 20, 2019March 20, 2019

Parkinson’s Disease is Associated with Dysregulations of a Dopamine-Modulated Gene Network Relevant to Sleep and Affective Neurobehaviors in the Striatum.

Parkinson's Disease Literature

Publication date: Mar 18, 2019 In addition to the characteristic motor symptoms, Parkinson’s disease (PD) often involves a constellation of sleep and mood symptoms. However, the mechanisms underlying these comorbidities ... Read more