Search Results for: Gene

February 23, 2020February 23, 2020

TERT, BRAF, and NRAS mutational heterogeneity between paired primary and metastatic melanoma tumors.

Melanoma Literature

Publication date: Feb 19, 2020 Mutational heterogeneity can contribute to therapeutic resistance in solid cancers. In melanoma, the frequency of inter- and intra-tumoral heterogeneity is controversial. We examined mutational heterogeneity ... Read more

February 23, 2020February 23, 2020

TERT, BRAF, and NRAS mutational heterogeneity between paired primary and metastatic melanoma tumors.

Melanoma Literature

February 23, 2020February 23, 2020

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism.

Melanoma Literature

Publication date: Feb 21, 2020 Second generation TRAIL-based therapeutics, combined with sensitising co-treatments, have recently entered clinical trials. However, reliable response predictors for optimal patient selection are not yet available. ... Read more

February 23, 2020February 23, 2020

Convergence of pathway analysis and pattern recognition predicts sensitization to latest generation TRAIL therapeutics by IAP antagonism.

Melanoma Literature

February 23, 2020February 23, 2020

The Hitchhiker’s Guide to Nucleocytoplasmic Trafficking in Neurodegeneration.

Huntington's Disease Literature

Publication date: Feb 21, 2020 The widespread nature of nucleocytoplasmic trafficking defects and protein accumulation suggests distinct yet overlapping mechanisms in a variety of neurodegenerative diseases. Detailed understanding of the ... Read more

February 23, 2020February 23, 2020

CD38 in Neurodegeneration and Neuroinflammation.

Parkinson's Disease Literature

Publication date: Feb 18, 2020 Neurodegenerative diseases are characterized by neuronal degeneration as well as neuroinflammation. While CD38 is strongly expressed in brain cells including neurons, astrocytes as well as ... Read more

February 23, 2020February 23, 2020

C/EBPβ/δ-secretase signaling mediates Parkinson’s disease pathogenesis via regulating transcription and proteolytic cleavage of α-synuclein and MAOB.

Parkinson's Disease Literature

Publication date: Feb 21, 2020 Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss and the presence of intra-neuronal Lewy body (LB) inclusions with aggregated ?-synuclein (?-Syn) as the major ... Read more

February 23, 2020February 23, 2020

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson’s disease modeling.

Parkinson's Disease Literature

Publication date: Feb 21, 2020 Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively ... Read more

February 23, 2020February 23, 2020

Genetics and major depressive disorder: clinical implications for disease risk, prognosis and treatment.

Major Depressive Disorder Literature

Publication date: Feb 18, 2020 In the post-genomic era, genetics has led to limited clinical applications in the diagnosis and treatment of major depressive disorder (MDD). Variants in genes coding ... Read more

February 23, 2020

Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice.

Autism Literature

Publication date: Feb 17, 2020 Aromatase catalyzes conversion of testosterone to estradiol and is expressed in a variety of tissues, including the brain. Suppression of aromatase adversely affects metabolism and ... Read more