Search Results for: Gene

September 20, 2019September 20, 2019

miR-140-5p is negatively correlated with proliferation, invasion, and tumorigenesis in malignant melanoma by targeting SOX4 via the Wnt/β-catenin and NF-κB cascades.

Melanoma Literature

Publication date: Aug 06, 2019 MicroRNAs (miRNAs) have been validated as critical regulators in the development of melanoma. miR-140 was abnormally downregulated in uveal melanoma samples. However, the expression level ... Read more

September 20, 2019September 20, 2019

A Multicenter Prospective Study of the Efficacy and Safety of Combined Immunosuppressive Therapy with High-Dose Glucocorticoid, Tacrolimus, and Cyclophosphamide in Interstitial Lung Diseases Accompanied by Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis.

Melanoma Literature

Publication date: Sep 16, 2019 Interstitial lung disease (ILD) accompanied by anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis (DM) is often rapidly progressive and associated with poor prognosis. Because there is ... Read more

September 20, 2019September 20, 2019

Heterogeneity of GNAQ/11 mutation inversely correlates with the metastatic rate in uveal melanoma.

Melanoma Literature

Publication date: Sep 18, 2019 To determine whether the GNAQ/11 mutation correlated with the outcome of patients with uveal melanoma (UM) when genetic heterogeneity was considered. We performed a retrospective ... Read more

September 20, 2019September 20, 2019

#ECTRIMS2019 – Ocrevus Living Up to ‘Game-changing’ Moniker, Genentech’s Hideki Garren Says in Interview

Multiple Sclerosis News

Publication date: Sep 19, 2019 Data presented at this year’s ECTRIMS conference compile the results of the main trial – the Phase 3 ORATORIO trial (NCT01194570) in PPMS patients – ... Read more

September 20, 2019

Parkinson disease genetics: too early to predict progression?

Parkinson's Disease Literature

Publication date: Sep 18, 2019 Kuhlenb”aumer, G. and Berg, D. Parkinson disease genetics: too early to predict progression? 22355. 2019 Nat Rev Neurol. Concepts Keywords Genetics Parkinson Semantics Type Source ... Read more

September 20, 2019September 20, 2019

Association between nucleotide-binding oligomerization domain protein 2 (NOD2) gene polymorphisms and Parkinson’s disease (PD) susceptibility.

Parkinson's Disease Literature

Publication date: Dec 01, 2019 Objective: This study aimed to explore the association between single nucleotide polymorphisms (SNPs) of nucleotide-binding oligomerization domain protein 2 (NOD2) gene and Parkinson’s disease susceptibility, ... Read more

September 19, 2019September 19, 2019

Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.

Melanoma Literature

Publication date: Sep 16, 2019 Life of patients with uveal melanoma (UM) is largely threatened by liver metastasis. Little is known about the drivers of liver organotropic metastasis in UM. ... Read more

September 19, 2019September 19, 2019

Melatonin exerts oncostatic capacity and decreases melanogenesis in human MNT-1 melanoma cells.

Melanoma Literature

Publication date: Sep 18, 2019 Melanogenesis is a key parameter of differentiation in melanocytes and melanoma cells; therefore, searches for factors regulating this pathway are strongly desired. Herein, we investigated ... Read more

September 19, 2019September 19, 2019

Tramadol prescribed use in general and chronic noncancer pain: a nationwide register-based cohort study of all patients above 16 years.

Opioids Literature

Publication date: Sep 17, 2019 Background and aims In the Western world, it has become clear that we are facing a crisis of overuse, abuse and improperly prescribed use of ... Read more

September 19, 2019September 19, 2019

Industry groups push back against ‘troubling’ FDA crackdown on genetic tests used to predict response to drugs

Precision Medicine News

Publication date: Sep 18, 2019 In recent weeks, the genetic testing world has been rattled by the Food and Drug Administration’s efforts to quietly pressure a number of companies to ... Read more