Search Results for: Gene

May 23, 2019May 23, 2019

Neuroblastoma RAS viral oncogene homolog mRNA is differentially spliced to give five distinct isoforms: implications for melanoma therapy.

Melanoma Literature

Publication date: May 20, 2019 Neuroblastoma RAS viral oncogene homolog is a commonly mutated oncogene in melanoma, and therapeutic targeting of neuroblastoma RAS viral oncogene homolog has proven difficult. We ... Read more

May 23, 2019May 23, 2019

Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status.

Melanoma Literature

Publication date: May 20, 2019 Tumor heterogeneity affects the efficacy of anticancer treatment as tumor subclones with distinct molecular patterns may be present within one tumor, leading to differing sensitivities ... Read more

May 23, 2019May 23, 2019

The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21.

Melanoma Literature

Publication date: May 21, 2019 Melanoma is the deadliest form of skin cancer, affecting men more frequently and severely than women. Although recent studies suggest that differences in activity of ... Read more

May 23, 2019May 23, 2019

Generation and comprehensive characterization of induced pluripotent stem cells for translational research.

Precision Medicine Literature

Publication date: May 22, 2019 Induced pluripotent stem cells (iPSCs) hold immense potential in disease modeling, drug discovery and regenerative medicine. Despite advances in reprogramming methods, generation of clinical-grade iPSCs ... Read more

May 22, 2019May 22, 2019

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins.

Huntington's Disease Literature

Publication date: May 20, 2019 There is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein ... Read more

May 22, 2019May 22, 2019

New Insights into Molecular Oncogenesis and Therapy of Uveal Melanoma.

Melanoma Literature

Publication date: May 19, 2019 Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in recent years by many teams in the field of biomedical ... Read more

May 22, 2019May 22, 2019

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.

Melanoma Literature

Publication date: May 21, 2019 Genotype-phenotype studies can identify subgroups of patients with specific clinical features or differing outcomes, which can help shape management. We undertook MC1R genotyping from blood, ... Read more

May 22, 2019May 22, 2019

A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis.

Multiple Sclerosis Literature

Publication date: May 20, 2019 Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology ... Read more

May 22, 2019May 22, 2019

The Impact of Epigenetics on Cardiovascular Disease.

Precision Medicine Literature

Publication date: May 21, 2019 Mortality and morbidity from the cardiovascular diseases (CVDs) represents a huge burden to society. It is recognized that environmental and individual lifestyle factors play important ... Read more

May 22, 2019May 22, 2019

Celgene and the Multiple Sclerosis Association of America Team Up to Launch MS MindShift for Awareness of Multiple Sclerosis and Brain Health

Multiple Sclerosis News

Publication date: May 22, 2019 SUMMIT, N. J.–(BUSINESS WIRE)–May 21, 2019– Celgene Corporation (NASDAQ: CELG) and the Multiple Sclerosis Association of America (MSAA) today announced the launch of a new ... Read more