Search Results for: Glutamatergic

December 7, 2019December 7, 2019

Structural Plasticity of GABAergic and Glutamatergic Networks in the Motor Thalamus of Parkinsonian Monkeys.

Publication date: Dec 06, 2019 In the primate thalamus, the parvocellular ventral anterior nucleus (VApc) and the centromedian nucleus (CM) receive GABAergic projections from the internal globus pallidus (GPi) and ... Read more

October 9, 2018October 9, 2018

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.

Multiple Sclerosis Literature

Publication date: Oct 08, 2018 Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous ... Read more

November 22, 2019November 22, 2019

Potentiation of morphine-induced antinociception by harmaline: involvement of μ-opioid and ventral tegmental area NMDA receptors.

Opioids Literature

Publication date: Nov 18, 2019 Morphine is one of the most well-known and potent analgesic agents; however, it can also induce various side effects. Thus, finding drugs and mechanisms which ... Read more

November 16, 2019November 16, 2019

Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.

Huntington's Disease Literature

Publication date: Nov 12, 2019 Excitatory amino acid transporters (EAATs) encompass a class of five transporters with distinct expression in neurons and glia of the central nervous system (CNS). EAATs ... Read more

November 8, 2019November 8, 2019

Does kynurenic acid act on nicotinic receptors? An assessment of the evidence.

Huntington's Disease Literature

Publication date: Nov 06, 2019 As a major metabolite of kynurenine in the oxidative metabolism of tryptophan, kynurenic acid is of considerable biological and clinical importance as an endogenous antagonist ... Read more

October 31, 2019October 31, 2019

A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo

Opioids News

Publication date: Oct 30, 2019 Proof of concept, double-blind Randomized Controlled Trial with d-Methadone proposed for the first time for use in the treatment of patients diagnosed with primary, moderate ... Read more

September 15, 2019September 15, 2019

Brain Zinc Deficiency Exacerbates Cognitive Decline in the R6/1 Model of Huntington’s Disease.

Huntington's Disease Literature

Publication date: Sep 13, 2019 There is currently no disease-modifying treatment for Huntington’s disease (HD), which is characterized by chorea motor impairment and cognitive decline. The zinc ionophore, PBT2, was ... Read more

July 10, 2019July 10, 2019

Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington’s Disease

Huntington's Disease News

Publication date: Jul 09, 2019 Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have ... Read more

May 29, 2019May 29, 2019

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons.

Multiple Sclerosis Literature

Publication date: May 24, 2019 The crucial step in the pathogenic events that lead to the development and the progression of Multiple Sclerosis (MS) is the infiltration of autoreactive T ... Read more

May 22, 2019May 22, 2019

Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease.

Multiple Sclerosis Literature

Publication date: May 17, 2019 Glia form a central component of the nervous system whose varied activities sustain an environment that is optimised for healthy development and neuronal function. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole ... Read more