Search Results for: Glutamatergic

October 9, 2018October 9, 2018

Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.

Publication date: Oct 08, 2018 Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous ... Read more

July 21, 2019July 21, 2019

Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation.

Parkinson's Disease Literature

Publication date: Jul 17, 2019 Magnetic fields with different frequency and intensity parameters exhibit a wide range of effects on different biological models. Extremely low frequency magnetic field (ELF MF) ... Read more

July 16, 2019July 16, 2019

Exercise proving a useful tool in fight against Parkinson’s disease

Parkinson's Disease News

Publication date: Jul 16, 2019 The following definition of Parkinson’s disease comes from the Michael J. Fox Foundation for Parkinson’s Research: -Parkinson’s disease (PD) occurs when brain cells that make ... Read more

July 10, 2019July 10, 2019

Study of BDNF Pathway Biomarkers in the Cerebrospinal Fluid in Patients With Huntington’s Disease

Huntington's Disease News

Publication date: Jul 09, 2019 Huntington disease (HD, 1.3/10 000) is an autosomal dominant disease due to an abnormal expansion of CAG triplets in HTT gene. Several pathophysiological mechanisms have ... Read more

June 27, 2019June 27, 2019

Metabotropic Receptors For Glutamate Type 3 In Parkinson’s

Parkinson's Disease News

Publication date: Jun 26, 2019 Parkinson’s disease (PD) is characterized by bradykinesia, rigidity, and tremor. Several scientific pieces of evidence, based on the use of kinematic techniques, have allowed quantifying ... Read more

May 29, 2019May 29, 2019

Peripheral T cells from multiple sclerosis patients trigger synaptotoxic alterations in central neurons.

Multiple Sclerosis Literature

Publication date: May 24, 2019 The crucial step in the pathogenic events that lead to the development and the progression of Multiple Sclerosis (MS) is the infiltration of autoreactive T ... Read more

May 22, 2019May 22, 2019

Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease.

Multiple Sclerosis Literature

Publication date: May 17, 2019 Glia form a central component of the nervous system whose varied activities sustain an environment that is optimised for healthy development and neuronal function. Alpha-amino-3-hydroxy-5-methyl-4-isoxazole ... Read more

April 17, 2019April 17, 2019

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1 Melanoma.

Melanoma Literature

Publication date: Apr 15, 2019 Aberrant glutamatergic signaling has been implicated in altered metabolic activity in many cancer types, including malignant melanoma. Previously, we have illustrated the role of metabotropic ... Read more

April 17, 2019April 17, 2019

Concurrent Targeting of Glutaminolysis and Metabotropic Glutamate Receptor 1 (GRM1) Reduces Glutamate Bioavailability in GRM1 Melanoma.

Melanoma Literature

April 9, 2019April 9, 2019

Glutamate versus GABA in neuron-oligodendroglia communication.

Multiple Sclerosis Literature

Publication date: Apr 07, 2019 In the central nervous system (CNS), myelin sheaths around axons are formed by glial cells named oligodendrocytes (OLs). In turn, OLs are generated by oligodendrocyte ... Read more