Search Results for: Hyaluronic acid

August 15, 2020August 15, 2020

Development of a carrier system containing hyaluronic acid and protamine for siRNA delivery in the treatment of melanoma.

Melanoma Literature

Publication date: Aug 13, 2020 The use of small interfering RNA (siRNA) in melanoma treatment remains limited owing to its biological properties. Herein, we developed a carrier system containing hyaluronic ... Read more

February 1, 2021February 1, 2021

Introduction of a model of skin lesions on rats and testing of dissolving microneedles containing 5-aminolevulinic acid.

Melanoma Literature

Publication date: Feb 01, 2021 Topical photodynamic therapy (PDT) is widely used to treat non melanoma skin cancers. It consists of topically applying on the skin lesions a cream containing ... Read more

July 10, 2021July 10, 2021

A dual macrophage polarizer conjugate for synergistic melanoma therapy.

Melanoma Literature

Publication date: Jul 10, 2021 Tumor associated macrophages (TAMs) play a paradoxical role in the fate of aggressive tumors like melanoma. Immune modulation of TAMs from the tumor-permissive M2 phenotype ... Read more

July 10, 2021July 10, 2021

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota.

Autism Literature

Publication date: Jul 08, 2021 Autism spectrum disorders (ASD) are associated with dysregulation of the microbiota-gut-brain axis, changes in microbiota composition as well as in the fecal, serum, and urine ... Read more

July 7, 2021July 7, 2021

Disrupting the α7nAChR-NR2A protein complex exerts antidepressant-like effects.

Major Depressive Disorder Literature

Publication date: Jul 05, 2021 Major depressive disorder (MDD) is associated with significant morbidity and mortality. Most antidepressant medications target the serotonin and norepinephrine transporters, but a significant minority of ... Read more

July 3, 2021July 3, 2021

Genetic dissection identifies Necdin as a driver gene in a mouse model of paternal 15q duplications.

Autism Literature

Publication date: Jul 01, 2021 Maternally inherited duplication of chromosome 15q11-q13 (Dup15q) is a pathogenic copy number variation (CNV) associated with autism spectrum disorder (ASD). Recently, paternally derived duplication has ... Read more

July 1, 2021July 1, 2021

The MS Fitness Challenge | S3E38

Multiple Sclerosis Media

Publication date: Jun 30, 2021 Meet David Lyons, bodybuilding champion, media personality and founder of a global fitness training program. Did we mention David also has MS? Through the MS ... Read more

July 1, 2021July 1, 2021

Do patients' resilience and subjective illness representation predict the outcome of a routine inpatient treatment program of major depressive disorder?

Major Depressive Disorder Literature

Publication date: Jun 30, 2021 Adopting a personalized medicine approach beyond genetic/epigenetic profiling within psychiatric diagnostic and treatment is challenging. For the first time, we studied the influence of two ... Read more

June 29, 2021June 29, 2021

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients

Multiple Sclerosis News

Publication date: Jun 27, 2021 Background Multiple Sclerosis (MS), the leading cause of non-traumatic neurological disability in young adults, is a chronic inflammatory and neurodegenerative disease of the central nervous ... Read more

June 6, 2021June 6, 2021

The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression.

Major Depressive Disorder Literature

Publication date: Jun 04, 2021 Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need ... Read more