Search Results for: Hypoxia

Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, Sc-Radiolabeling, and Preclinical Assessment.

Sc(III) Complexes of Pyclen Derivative Ligands as Probes for Hypoxia: Synthesis, Chemical Characterization, Sc-Radiolabeling, and Preclinical Assessment.

Melanoma Literature
Publication date: Nov 18, 2025 Rigid pyclen derivative ligands bearing hypoxia-sensitive nitroimidazole (NI) pendants, PC2A-Ph-NI (hexadentate) and PC2AM-NI (heptadentate), were synthesized, radiolabeled with Sc(III), and evaluated under preclinical circumstances. Physicochemical ... Read more