Search Results for: Inhibitors

March 22, 2025March 22, 2025

Novel Benzosuberone/Indanone-Linked Thiazoles as Small-Molecule SARS-CoV-2 Main Protease Inhibitors.

Publication date: Apr 01, 2025 Herein, novel benzosuberone/indanone-linked thiazoles were designed and synthesized as small-molecule SARS-CoV-2 Main protease (M) inhibitors with potential anti-COVID activity. All thiazole derivatives were synthesized from ... Read more

March 22, 2025March 22, 2025

Structural insights into the RNA binding inhibitors of the C-terminal domain of the SARS-CoV-2 nucleocapsid.

Coronavirus Literature

Publication date: Mar 18, 2025 The SARS-CoV-2 nucleocapsid (N) protein is an essential structural element of the virion, playing a crucial role in enclosing the viral genome into a ribonucleoprotein ... Read more

March 22, 2025March 22, 2025

Identification of Natural Compounds as Potential COVID-19 Main Protease (Mpro) Inhibitors: A Comprehensive Study and In silico Evidence.

Coronavirus Literature

Publication date: Mar 18, 2025 SARS-CoV-2, the virus responsible for COVID-19, has resulted in a devastating global impact with millions of lives lost. Remdesivir and 2-DG are among the few ... Read more

March 22, 2025March 22, 2025

Structural insights into the RNA binding inhibitors of the C-terminal domain of the SARS-CoV-2 nucleocapsid.

Coronavirus Literature

March 22, 2025March 22, 2025

Identification of Natural Compounds as Potential COVID-19 Main Protease (Mpro) Inhibitors: A Comprehensive Study and In silico Evidence.

Coronavirus Literature

March 21, 2025March 21, 2025

Selective serotonin reuptake inhibitors in the treatment of major depressive disorder after brain trauma: Systematic review and meta-analysis.

Major Depressive Disorder Literature

Publication date: Mar 19, 2025 Traumatic brain injury (TBI) poses a considerable risk to human health. After TBI, individuals are susceptible to a range of psychiatric disorders, with depression being ... Read more

March 21, 2025March 21, 2025

Dual role of interferon-gamma in the response of melanoma patients to immunotherapy with immune checkpoint inhibitors.

Melanoma Literature

Publication date: Mar 20, 2025 Interferon-gamma (IFN-γ) is a cytokine produced mainly by immune cells and can affect cancer cells by modulating the activity of multiple signaling pathways, including the ... Read more

March 20, 2025March 20, 2025

Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer.

Melanoma Literature

Publication date: Mar 19, 2025 BRAF-mutated colorectal cancer correlates with poor prognosis and limited response to standard treatments. Combining immune checkpoint inhibitors with BRAF/MEK inhibitors shows promise against BRAF-mutant melanoma ... Read more

March 19, 2025March 19, 2025

Association of proprotein convertase subtilisin/kexin type-9 inhibitors with risk of nonmelanoma skin cancer: a retrospective cohort study.

Melanoma Literature

Publication date: Mar 18, 2025 Growing evidence has shown that cholesterol metabolism abnormalities involve carcinogenesis. Proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors have been reported to inhibit tumour progression and prevent ... Read more

March 19, 2025March 19, 2025

TNF signature in advanced melanoma patients treated with immune checkpoint inhibitors: Results from the MELANFα clinical study.

Melanoma Literature

Publication date: Mar 18, 2025 Resistance to immune checkpoint inhibitors (ICI) in cancer patients is not fully understood, and predictive biomarkers are lacking. MELANFα (NCT03348891) is an open-label, prospective, multicenter ... Read more