Search Results for: Iron

January 21, 2025January 21, 2025

Second-generation BRAF inhibitor Encorafenib resistance is regulated by NCOA4-mediated iron trafficking in the drug-resistant malignant melanoma cells.

Melanoma Literature

Publication date: Jan 18, 2025 The current study established the first in vitro Encorafenib resistance protocol in BRAF-mutated malignant melanoma (MM) cells and investigated the resistance-related mechanisms. After establishing Encorafenib-resistant ... Read more

January 19, 2025January 19, 2025

The tumor immune microenvironment in primary cutaneous melanoma.

Melanoma Literature

Publication date: Jan 18, 2025 Melanoma is an immunogenic tumor. The melanoma tumor immune microenvironment (TIME) is made up of a heterogenous mix of both immune and non-immune cells as ... Read more

January 18, 2025January 18, 2025

Skin cancer treatment environment and survivorship resources among sexual and gender minority patients: results of the OUT National Cancer Survey.

Melanoma Literature

Publication date: Jan 16, 2025 Sexual and gender minority (SGM) cancer survivors face unmet care needs in accessing cancer health information and social support despite high satisfaction with treatment. SGM ... Read more

January 18, 2025January 18, 2025

Effectiveness of Buspirone in Alleviating Anxiety Symptoms in Patients with Depressive Disorder: A Multicenter Prospective Observational Study in Korea.

Major Depressive Disorder Literature

Publication date: Feb 28, 2025 We aimed to investigate the effectiveness of buspirone as an adjunctive therapy for alleviating anxiety symptoms in patients with depressive disorders who are already taking ... Read more

January 17, 2025January 17, 2025

Dopamine degrades ferritin by chaperone-mediated autophagy to elevate mitochondrial iron level in astroglial cells.

Parkinson's Disease Literature

Publication date: Jan 14, 2025 Iron accumulation and mitochondrial dysfunction in astroglia are reported in Parkinson’s disease (PD). Astroglia control iron availability in neurons in which dopamine (DA) synthesis is ... Read more

January 16, 2025January 16, 2025

Environmental Mycotoxins: A Potential Etiological Factor for Neurodegenerative Diseases?

Parkinson's Disease Literature

Publication date: Jan 13, 2025 Mycotoxins are potential environmental risk factors for neurodegenerative diseases. These toxins penetrate the central nervous system via a compromised blood-brain barrier, which may cause oxidative ... Read more

January 16, 2025January 16, 2025

Iron(ing) out parkinsonisms: The interplay of proteinopathy and ferroptosis in Parkinson’s disease and tau-related parkinsonisms.

Parkinson's Disease Literature

Publication date: Feb 01, 2025 Parkinsonian syndromes are characterised by similar motor-related symptomology resulting from dopaminergic neuron damage. While Parkinson’s disease (PD) is the most prevalent parkinsonism, we also focus ... Read more

January 16, 2025January 16, 2025

In a paradigm shift for autism, practitioners move beyond traditional demographics and toward adaptive environments

Autism News

Publication date: Jan 16, 2025 Autistic individuals frequently mask their traits to conform to non-autistic social norms, which can be both mentally and physically exhausting. One in 36 people have ... Read more

January 15, 2025January 15, 2025

Nonlinear relationship between physical environment risks, investor attentions, and financial systemic risks: Evidence from mLSTM-CoVaR networks.

Coronavirus Literature

Publication date: Jan 13, 2025 How do physical environment risks affect financial market systemic risk? We use remoting data to measure physical environment risks and select 26 banks across 12 ... Read more

January 14, 2025January 14, 2025

Peripheral blood immune cells from individuals with Parkinson’s disease or inflammatory bowel disease share deficits in iron storage and transport that are modulated by non-steroidal anti-inflammatory drugs.

Parkinson's Disease Literature

Publication date: Jan 11, 2025 Parkinson’s Disease (PD) is a multisystem disorder in which dysregulated neuroimmune crosstalk and inflammatory relay via the gut-blood-brain axis have been implicated in PD pathogenesis. ... Read more