Search Results for: L-Valine

June 22, 2019June 22, 2019

Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls.

Publication date: Apr 03, 2019 A top priority in biomarker development for Alzheimer’s disease (AD) and Parkinson’s disease (PD) is the focus on early diagnosis, where the use of the ... Read more

June 19, 2019June 19, 2019

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study.

Multiple Sclerosis Literature

Publication date: Jan 27, 2019 To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a diet-based multimodal intervention. This pilot study ... Read more

June 19, 2019June 19, 2019

A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies.

Precision Medicine Literature

Publication date: Jun 17, 2019 The availability and generation of large amounts of genomic data has led to the development of a new paradigm in cancer treatment emphasizing a precision ... Read more

June 17, 2019June 17, 2019

An update on Peginterferon beta-1a Management in Multiple Sclerosis: results from an interdisciplinary Board of German and Austrian Neurologists and dermatologists.

Multiple Sclerosis Literature

Publication date: Jun 15, 2019 Interferon (IFN) beta drugs have been approved for the treatment of relapsing forms of multiple sclerosis (RMS) for more than 20 years and are considered to ... Read more

June 17, 2019June 17, 2019

Pattern of cortical thinning associated with the BDNF Val66Met polymorphism in Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jun 13, 2019 The brain-derived neurotrophic factor (BDNF) valmet polymorphism has been suggested to modulate cognitive deterioration in Parkinson’s disease (PD). In particular, the val/val genotype has been ... Read more

June 15, 2019June 15, 2019

A dropout-regularized classifier development approach optimized for precision medicine test discovery from omics data.

Precision Medicine Literature

Publication date: Jun 13, 2019 Modern genomic and proteomic profiling methods produce large amounts of data from tissue and blood-based samples that are of potential utility for improving patient care. ... Read more

June 4, 2019June 4, 2019

Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging.

Multiple Sclerosis Literature

Publication date: May 31, 2019 Extensive gray matter (GM) involvement has been demonstrated in multiple sclerosis (MS) patients. This study was aimed to identify GM alterations in relapsing-remitting MS (RRMS) ... Read more

May 16, 2019May 16, 2019

Incidence, features, and prognosis of immune-related adverse events involving the thyroid gland induced by nivolumab.

Melanoma Literature

Publication date: Jan 15, 2019 Blocking the PD-1 pathway induces immune-related adverse events (irAEs) which often involve the thyroid gland (thyroid irAEs). Clinical features of a thyroid irAE including its ... Read more

May 1, 2019May 1, 2019

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells.

Melanoma Literature

Publication date: Apr 29, 2019 Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. While these ... Read more

April 20, 2019April 20, 2019

A Dynamic Bayesian Network model for the simulation of Amyotrophic Lateral Sclerosis progression.

Precision Medicine Literature

Publication date: Apr 18, 2019 Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease progressively affecting upper and lower motor neurons in the brain and spinal cord. Mean life expectancy ... Read more