Search Results for: L-Valine

September 13, 2019September 13, 2019

Metabolic biomarker based BRAFV600 mutation association and prediction in melanoma.

Melanoma Literature

Publication date: Sep 03, 2019 The aim of this study was to associate and predict B-Rapidly Accelerated Fibrosarcoma Valine 600 (BRAFV600) mutation status with both conventional- and radiomics fluorodeoxyglucose Positron ... Read more

August 31, 2019August 31, 2019

Looking beyond the hype: Applied AI and machine learning in translational medicine.

Precision Medicine Literature

Publication date: Aug 26, 2019 Big data problems are becoming more prevalent for laboratory scientists who look to make clinical impact. A large part of this is due to increased ... Read more

August 25, 2019August 25, 2019

Variant Interpretation for Cancer (VIC): a computational tool for assessing clinical impacts of somatic variants.

Precision Medicine Literature

Publication date: Aug 23, 2019 Clinical laboratories implement a variety of measures to classify somatic sequence variants and identify clinically significant variants to facilitate the implementation of precision medicine. To ... Read more

August 10, 2019August 10, 2019

Computational analysis of high-risk SNPs in human CHK2 gene responsible for hereditary breast cancer: A functional and structural impact.

Precision Medicine Literature

Publication date: Feb 04, 2019 Nowadays CHK2 mutation is studied frequently in hereditary breast and ovarian cancer patients in addition to BRCA1/BRCA2. CHK2 is a tumor suppressor gene that encodes ... Read more

July 31, 2019July 31, 2019

Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy.

Melanoma Literature

Publication date: Jul 29, 2019 Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to ... Read more

July 18, 2019July 18, 2019

MR susceptibility contrast imaging using a 2D simultaneous multi-slice gradient-echo sequence at 7T.

Multiple Sclerosis Literature

Publication date: Mar 12, 2019 To develop a 7T simultaneous multi-slice (SMS) 2D gradient-echo sequence for susceptibility contrast imaging, and to compare its quality to 3D imaging. A frequency modulated ... Read more

July 13, 2019July 13, 2019

Predicting drug activity against cancer cells by random forest models based on minimal genomic information and chemical properties.

Precision Medicine Literature

Publication date: Nov 01, 2018 A key goal of precision medicine is predicting the best drug therapy for a specific patient from genomic information. In oncology, cancers that appear similar ... Read more

June 19, 2019June 19, 2019

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study.

Multiple Sclerosis Literature

Publication date: Jan 27, 2019 To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a diet-based multimodal intervention. This pilot study ... Read more

June 19, 2019June 19, 2019

A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies.

Precision Medicine Literature

Publication date: Jun 17, 2019 The availability and generation of large amounts of genomic data has led to the development of a new paradigm in cancer treatment emphasizing a precision ... Read more

June 17, 2019June 17, 2019

An update on Peginterferon beta-1a Management in Multiple Sclerosis: results from an interdisciplinary Board of German and Austrian Neurologists and dermatologists.

Multiple Sclerosis Literature

Publication date: Jun 15, 2019 Interferon (IFN) beta drugs have been approved for the treatment of relapsing forms of multiple sclerosis (RMS) for more than 20 years and are considered to ... Read more