Publication date: Oct 24, 2019 This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been ... Read more

Publication date: Oct 18, 2019 Recent advances obtained with immune checkpoint inhibitors (ICIs) targeting the Programmed cell death-1 (PD-1) protein have significantly improved the outcome of patients with metastatic melanoma. ... Read more

Publication date: Oct 17, 2019 Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and ... Read more

Publication date: Sep 30, 2019 Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) has been tested in advanced melanoma patients at various centers. We conducted a systematic review and ... Read more

Publication date: Sep 18, 2019 The pervasive use of therapeutic antibodies targeting PD-1 to boost anti-tumor immunity has positioned this approach to become the standard-of-care for some solid tumor malignancies. ... Read more

Publication date: Sep 04, 2019 Only a small fraction of patients with cancer receiving immune checkpoint therapy (ICT) respond, which is associated with tumor immune microenvironment (TIME) subtypes and tumor-infiltrating ... Read more

Publication date: Aug 24, 2019 Lymphocytic infiltration into melanoma tissue is an important prerequisite for effective anti-tumoral immunity. However, analysis of human metastatic melanoma has shown that leukocyte adhesion receptor ... Read more

Publication date: Jul 29, 2019 Tumor-associated antigen cytotoxic T cells (TAA-Ts) represent a new, potentially effective and nontoxic therapeutic approach for patients with relapsed or refractory solid tumors. In this ... Read more

Publication date: Jul 02, 2019 This decade has introduced drastic changes in melanoma therapy, predominantly due to the materialization of the long promise of immunotherapy. Cytotoxic T cells are the ... Read more