Search Results for: Lymphocytes

January 3, 2020January 3, 2020

Cytologic Evaluation of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.

Melanoma Literature

Publication date: Jan 02, 2020 Novel immunotherapeutic options for refractory metastatic cancer patients include adoptive cell therapies such as tumor infiltrating lymphocytes (TILs). This study characterizes the clinicopathologic findings in ... Read more

October 29, 2019October 29, 2019

Tumor infiltrating lymphocytes in malignant melanoma – allies or foes?

Melanoma Literature

Publication date: Oct 24, 2019 This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been ... Read more

October 19, 2019October 19, 2019

Association of combined PD-L1 expression and tumor-infiltrating lymphocytes features with survival and treatment outcomes in patients with metastatic melanoma.

Melanoma Literature

Publication date: Oct 18, 2019 Recent advances obtained with immune checkpoint inhibitors (ICIs) targeting the Programmed cell death-1 (PD-1) protein have significantly improved the outcome of patients with metastatic melanoma. ... Read more

October 18, 2019October 18, 2019

Level of tumor-infiltrating lymphocytes and density of infiltrating immune cells in different malignancies.

Melanoma Literature

Publication date: Oct 17, 2019 Aim: To correlate levels of tumor-infiltrating lymphocytes (TIL) evaluated using the International Immuno-Oncology Biomarker Working Group methodology, and both density of tumor-infiltrating immune cell and ... Read more

October 4, 2019October 4, 2019

Efficacy of Adoptive Therapy with Tumor-infiltrating Lymphocytes and Recombinant Interleukin-2 in Advanced Cutaneous Melanoma: A Systematic Review and Meta-analysis.

Melanoma Literature

Publication date: Sep 30, 2019 Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) has been tested in advanced melanoma patients at various centers. We conducted a systematic review and ... Read more

September 19, 2019September 19, 2019

Exposure to anti-PD-1 causes functional differences in tumor-infiltrating lymphocytes in rare solid tumors.

Melanoma Literature

Publication date: Sep 18, 2019 The pervasive use of therapeutic antibodies targeting PD-1 to boost anti-tumor immunity has positioned this approach to become the standard-of-care for some solid tumor malignancies. ... Read more

September 7, 2019September 7, 2019

Association of Germline Variants in Natural Killer Cells With Tumor Immune Microenvironment Subtypes, Tumor-Infiltrating Lymphocytes, Immunotherapy Response, Clinical Outcomes, and Cancer Risk.

Melanoma Literature

Publication date: Sep 04, 2019 Only a small fraction of patients with cancer receiving immune checkpoint therapy (ICT) respond, which is associated with tumor immune microenvironment (TIME) subtypes and tumor-infiltrating ... Read more

August 25, 2019August 25, 2019

Activation of human vascular endothelium in melanoma metastases induces ICAM-1 and E-selectin expression and results in increased infiltration with effector lymphocytes.

Melanoma Literature

Publication date: Aug 24, 2019 Lymphocytic infiltration into melanoma tissue is an important prerequisite for effective anti-tumoral immunity. However, analysis of human metastatic melanoma has shown that leukocyte adhesion receptor ... Read more

$Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multiantigen-Associated Specific Cytotoxic T Lymphocytes: A Phase I Study.$

July 30, 2019July 30, 2019

Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multiantigen-Associated Specific Cytotoxic T Lymphocytes: A Phase I Study.

Melanoma Literature

Publication date: Jul 29, 2019 Tumor-associated antigen cytotoxic T cells (TAA-Ts) represent a new, potentially effective and nontoxic therapeutic approach for patients with relapsed or refractory solid tumors. In this ... Read more

July 7, 2019July 7, 2019

Theiler’s murine encephalomyelitis virus infection of astrocytes induces the expression of chemokines which attract activated but not resting T lymphocytes.

Multiple Sclerosis Literature

Publication date: Jul 05, 2019 In this article, we studied the production of the chemokine CXCL9, also termed Mig (monokine induced by gamma interferon) by cultured SJL/J mouse astrocytes infected ... Read more