Search Results for: MCL1

November 16, 2019November 16, 2019

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Melanoma Literature

Publication date: Nov 14, 2019 BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops. Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway inhibition is ... Read more

November 22, 2019November 22, 2019

Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death.

Melanoma Literature

Publication date: Nov 19, 2019 Mutation of the oncogene BRAF is among the most common genetic alterations in melanoma. BRAF inhibitors alone or in combination with MEK inhibitors fail to ... Read more

November 12, 2019November 12, 2019

Future drugs aimed at halting cell-inactivation process may help prevent Parkinson’s disease

Parkinson's Disease News

Publication date: Nov 12, 2019 In neurodegenerative conditions like Parkinson’s disease, a specific group of neurons start to die one by one, causing movement problems and other symptoms. But the ... Read more

July 27, 2019July 27, 2019

HealthWatch: Intermittent Fasting for Multiple Sclerosis

Multiple Sclerosis News

Publication date: Jul 27, 2019 Anne Haney Cross, MD, Professor of Neurology at the Washington University St. Louis is hopeful too. -Intermittent fasting reduces the inflammatory profile in the blood ... Read more

July 18, 2019July 18, 2019

Why we need a small data paradigm.

Precision Medicine Literature

Publication date: Jul 17, 2019 There is great interest in and excitement about the concept of personalized or precision medicine and, in particular, advancing this vision via various ‘big data’ ... Read more

July 9, 2019July 9, 2019

Why the absence of hope may be hurting Huntington’s disease research

Huntington's Disease News

Publication date: Jul 09, 2019 The author of those words is George Huntington, the physician credited with defining the disease that carries his name, Huntington’s Disease, a genetic, invariably fatal, ... Read more

July 6, 2019July 6, 2019

The bite that cures: how we’re turning venom into medicine

Precision Medicine News

Publication date: Jul 06, 2019 Venoms are cocktails made up of between tens and hundreds of different toxins, usually proteins and smaller chains of amino acids similar to proteins called ... Read more

July 5, 2019July 5, 2019

Intermittent Fasting for Multiple Sclerosis

Multiple Sclerosis News

Publication date: Jul 05, 2019 Today, she’s getting blood drawn to measure the benefits of intermittent fasting. “Intermittent fasting reduces the inflammatory profile in the blood and possibly in the ... Read more

July 4, 2019July 4, 2019

Omega-3s and Multiple Sclerosis

Multiple Sclerosis News

Publication date: Jul 04, 2019 But according to the National Multiple Sclerosis Society, MS appears to strike when a number of factors combine: Genetic predisposition Environmental factors such as pollution ... Read more

June 30, 2019June 30, 2019

Population-scale DNA test could make personalized medicine effective and affordable for all

Precision Medicine News

Publication date: Jun 30, 2019 The EU-funded EPERMED project has developed innovative tools and techniques to create gene maps of individuals in order to calculate their genetic risk of developing ... Read more