Search Results for: Medical specialties

January 1, 2020January 1, 2020

Individualizing Care: Management Beyond Medical Therapy.

Publication date: Jan 01, 2020 The evolving research landscape, with advances in the omics technologies, availability of large-scale patient cohorts, and forthcoming availability of novel drugs in primary biliary cholangitis ... Read more

March 29, 2020

The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark): study design and population.

Parkinson's Disease Literature

Publication date: Mar 26, 2020 The Bologna motor and non-motor prospective study on parkinsonism at onset (BoProPark) was designed to prospectively characterize motor and non-motor features in patients with a ... Read more

March 29, 2020

Influence of levodopa on orthostatic hypotension in Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Mar 27, 2020 Orthostatic hypotension presents in all phases of Parkinson’s Disease (PD) and occurs in about 80% of patients. There is some debate in the literature as ... Read more

March 28, 2020

Effect of phenytoin on retinal ganglion cells in acute isolated optic neuritis.

Multiple Sclerosis Literature

Publication date: Mar 24, 2020 Phenytoin has been shown to reduce the peripapillary retinal nerve fiber layer (pRNFL) loss in optic neuritis (ON). We evaluated the effects of phenytoin on ... Read more

March 28, 2020March 28, 2020

PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.

Melanoma Literature

Publication date: Jul 14, 2019 The increased PD-L1 expression induces poorer prognosis in melanoma. The small molecule inhibitors of PD-1/PD-L1 pathways have been an encouraging drug development strategy because of ... Read more

March 28, 2020

Donor lymphocyte-derived natural killer cells control major histocompatibility complex class I-negative melanoma.

Melanoma Literature

Publication date: Mar 24, 2020 Natural killer (NK) cells provide a natural defense against MHC-I-negative tumors, such as melanoma. Donor lymphocyte infusion (DLI) containing NK cells, a form of adoptive ... Read more

March 28, 2020March 28, 2020

Inhibition of MICA and MICB Shedding Elicits NK cell-mediated Immunity against Tumors Resistant to Cytotoxic T cells.

Melanoma Literature

Publication date: Mar 24, 2020 Resistance to cytotoxic T cells is frequently mediated by loss of MHC class I expression or IFN? signaling in tumor cells, such as mutations of ... Read more

March 28, 2020March 28, 2020

Suppression of Ca signals by EGR4 controls Th1 differentiation and anti-cancer immunity in vivo.

Melanoma Literature

Publication date: Mar 25, 2020 While the zinc finger transcription factors EGR1, EGR2, and EGR3 are recognized as critical for T-cell function, the role of EGR4 remains unstudied. Here, we ... Read more

March 28, 2020March 28, 2020

Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8+ T cells to memory T cells.

Melanoma Literature

Publication date: Mar 25, 2020 Clinical response rates after adoptive cell therapy (ACT) are highly correlated with in vivo persistence of the infused T cells. However, antigen-specific T cells found ... Read more

March 28, 2020

Ex vivo-generated dendritic cell-based vaccines in melanoma: the role of nanoparticulate delivery systems.

Melanoma Literature

Publication date: Mar 26, 2020 Melanoma is a poor immunogenic cancer and many treatment strategies have been used to enhance specific or nonspecific immunity against it. Dendritic cell (DC)-based cancer ... Read more