Search Results for: Mendelian randomization

May 15, 2025

Exploring glucagon-like peptide-1 receptor agonists as potential disease-modifying agent in psychiatric and neurodevelopmental conditions: evidence from a drug target Mendelian randomization.

Autism Literature

Publication date: May 14, 2025 Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have recently received Food and Drug Administration (FDA) approval for obesity management. However, the causal relationship between GLP-1RAs and psychiatric ... Read more

May 14, 2025

Genetic liability to critically ill COVID-19 increased risk of HER2-positive breast cancer through the immune pathway: A Mendelian randomization study.

Coronavirus Literature

Publication date: May 09, 2025 The clinical management of patients with both coronavirus disease 2019 (COVID-19) and breast cancer remains a complex and unresolved issue that despite extensive discussion has ... Read more

May 13, 2025

Micronutrients and skin cancer risk: a Mendelian randomization study.

Melanoma Literature

Publication date: May 11, 2025 The intake of micronutrients is linked to cancer risk, but their specific mechanisms in skin cancer remain unclear. This study systematically investigated the causal effects ... Read more

May 9, 2025May 9, 2025

Separating the effects of childhood and adult obesity on depression, subjective well-being, and suicide attempt: a Mendelian randomization study.

Major Depressive Disorder Literature

Publication date: May 08, 2025 Observational studies have linked obesity, both in childhood and adulthood, with higher risks of depression, reduced subjective well-being (SWB), and suicide attempts (SA). However, the ... Read more

May 8, 2025May 8, 2025

Identifying novel protein biomarkers with cross-psychiatric disorders effects and potential intervention targets: Evidence from proteomic-Mendelian randomization.

Major Depressive Disorder Literature

Publication date: May 05, 2025 Plasma proteins are the potential therapeutic targets for psychiatric disorders due to their important roles in signal transduction. We aimed to explore the plasma protein ... Read more

May 3, 2025

Is Metabolic Syndrome a Risk Factor for Skin Cancer? A UK Biobank Observational and Two-Sample Mendelian Randomization Study.

Melanoma Literature

Publication date: May 02, 2025 Skin cancers are the third most common cancer worldwide, with incidence increasing. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities strongly associated with the ... Read more

May 2, 2025

Investigating causal relationships between gene expression and major depressive disorder via brain bulk-tissue and cell type-specific eQTL: A Mendelian randomization and Bayesian colocalization study.

Major Depressive Disorder Literature

Publication date: Apr 29, 2025 Major depressive disorder (MDD) is a highly prevalent psychiatric disorder with complex genetic underpinnings. While genome-wide association studies (GWAS) have identified multiple risk loci, pinpointing ... Read more

May 1, 2025

No Bidirectional Causal Relationship Between Traumatic Brain Injury and Parkinson’s Disease: A Two-Sample Mendelian Randomization Study.

Parkinson's Disease Literature

Publication date: May 01, 2025 The incidence of Parkinson’s disease (PD) is significantly increased in older people who have experienced traumatic brain injury (TBI), suggesting that TBI may be a ... Read more

May 1, 2025

Causal associations between congenital adrenal hyperplasia and neuropsychiatric conditions- a Mendelian Randomization Study.

Autism Literature

Publication date: Apr 30, 2025 Congenital adrenal hyperplasia (CAH), predominantly caused by 21-hydroxylase deficiency (21-OHD) due to CYP21A2 mutations, disrupts cortisol synthesis and adrenal androgen homeostasis. Observational studies suggest CAH ... Read more

May 1, 2025

The relationship between COVID-19 and stroke and its risk factors, a Mendelian randomization analysis.

Coronavirus Literature

Publication date: Apr 30, 2025 It remains unclear about the association between stroke and Coronavirus disease 2019 (COVID-19). Therefore, a Mendelian randomization (MR) analysis was conducted to explore the relationship ... Read more