Search Results for: Metabolism

January 18, 2025January 18, 2025

Understanding glucose metabolism and insulin action at the blood-brain barrier: Implications for brain health and neurodegenerative diseases.

Publication date: Feb 01, 2025 The blood-brain barrier (BBB) is a highly selective, semipermeable barrier critical for maintaining brain homeostasis. The BBB regulates the transport of essential nutrients, hormones, and ... Read more

January 14, 2025January 14, 2025

Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors

Major Depressive Disorder News

Publication date: Jan 12, 2025 Alterations in the kynurenine pathway, and in particular the balance of neuroprotective and neurotoxic metabolites, have been implicated in the pathophysiology of Major Depressive Disorder ... Read more

January 10, 2025January 10, 2025

Glucose metabolism impairment in major depressive disorder.

Major Depressive Disorder Literature

Publication date: Jan 07, 2025 Major depressive disorder (MDD) is a common mental disorder with chronic tendencies that seriously affect regular work, life, and study. However, its exact pathogenesis remains ... Read more

January 9, 2025January 9, 2025

Tryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson’s disease and insomnia.

Parkinson's Disease Literature

Publication date: Jan 08, 2025 Parkinson’s disease (PD) and insomnia are prevalent neurological disorders, with emerging evidence implicating tryptophan (TRP) metabolism in their pathogenesis. However, the precise mechanisms by which ... Read more

January 9, 2025January 9, 2025

Cholesterol Metabolism in CNS Diseases: The Potential of SREBP2 and LXR as Therapeutic Targets.

Huntington's Disease Literature

Publication date: Jan 07, 2025 The brain is the organ with the highest cholesterol content in the body. Cholesterol in the brain plays a crucial role in maintaining the integrity ... Read more

December 30, 2024December 30, 2024

Plasma metabolomics profiles indicate sex differences of lipid metabolism in patients with Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Dec 28, 2024 The effect of sexual dimorphism on the metabolism of patients with Parkinson’s disease has not been clarified. A group of patients with Parkinson’s disease and ... Read more

December 27, 2024December 27, 2024

Targeting Glucose Metabolism: A Novel Therapeutic Approach for Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Nov 13, 2024 Glucose metabolism is essential for the maintenance and function of the central nervous system. Although the brain constitutes only 2% of the body weight, it ... Read more

December 27, 2024December 27, 2024

Glucose Metabolism Disorders and Parkinson’s Disease: Coincidence or Indicator of Dysautonomia?

Parkinson's Disease Literature

Publication date: Dec 06, 2024 Background: Parkinson’s disease (PD) and type 2 diabetes mellitus (T2DM) are both age-related diseases. Evidence from recent studies suggests a link between them. The existence ... Read more

December 25, 2024December 25, 2024

Gut microbiota dysbiosis promotes cognitive impairment via bile acid metabolism in major depressive disorder.

Major Depressive Disorder Literature

Publication date: Dec 24, 2024 Evidence suggests that complex interactions among the gut microbiome, metabolic abnormalities, and brain have important etiological and therapeutic implications in major depressive disorder (MDD). However, ... Read more

December 22, 2024December 22, 2024

Overexpression of α-synuclein in PDF neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila.

Parkinson's Disease Literature

Publication date: Dec 21, 2024 Parkinson’s disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence of sleep-wake disorders in ... Read more