Publication date: Jul 08, 2019 Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults. With over 50% of patients developing metastatic disease, there is an unmet need ... Read more

Publication date: Jul 08, 2019 There is little evidence that smoking is associated with metastasis in patients with cutaneous melanoma. Using a propensity score matching analysis, we assessed whether smoking ... Read more

Publication date: Jun 12, 2019 Uveal melanoma (UM) is the most frequently found primary intra-ocular tumor in adults. It is a highly aggressive cancer that causes metastasis-related mortality in up ... Read more

Publication date: Jul 01, 2019 Metastatic brain tumors are the most common brain tumors in adults. With numerous successful advancements in systemic treatment of most common cancer types, brain metastasis ... Read more

Publication date: May 30, 2019 Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using ... Read more

Publication date: Jun 21, 2019 Patients with liver metastases of uveal melanoma (LMUM) die from their metastatic evolution within 2 years. We established a nomogram to choose a treatment adapted ... Read more

Publication date: Jun 18, 2019 The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase frequently altered in various human cancers, including melanomas. Despite its important roles in translation and ... Read more

Publication date: Jun 17, 2019 Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and is involved in tumor metastasis and malignant progression. In previous studies, we generated a ... Read more

Publication date: Jun 14, 2019 Approximately 60% of melanoma have BRAF mutation which leads to the abnormal activation of MAPK signaling pathway. Therefore, targeting these signaling pathways is particularly important ... Read more

Publication date: May 22, 2019 Aerobic glycolysis is a hallmark of cancer. Sine oculis homeobox 1 (SIX1), a key transcription factor in terms of regulating aerobic glycolysis (the Warburg Effect), ... Read more