Search Results for: Methionine

January 11, 2019January 11, 2019

Methionine Antagonizes para-Aminosalicylic Acid Activity via Affecting Folate Precursor Biosynthesis in Mycobacterium tuberculosis.

Publication date: May 13, 2018 para-Aminosalicylic acid (PAS) is a second-line anti-tubercular drug that is used for the treatment of drug-resistant tuberculosis (TB). PAS efficacy in the treatment of TB ... Read more

November 15, 2018November 15, 2018

1,25-Dihydroxyvitamin D increases the methionine cycle, CD4 T cell DNA methylation and HeliosFoxp3 T regulatory cells to reverse autoimmune neurodegenerative disease.

Multiple Sclerosis Literature

Publication date: Nov 15, 2018 We investigated how one calcitriol dose plus vitamin D reverses experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. This protocol rapidly increased CD4 T cell ... Read more

August 17, 2018August 17, 2018

A frontal tumefactive demyelinating lesion mimicking glioblastoma differentiated by methionine positron emission tomography.

Multiple Sclerosis Literature

Publication date: Aug 13, 2018 Tumefactive demyelinating lesion (TDL) is often reported as a rare variation of multiple sclerosis (MS). TDL is difficult to diagnose solely by magnetic resonance imaging ... Read more

June 26, 2018June 26, 2018

Modulation of Dietary Methionine Intake Elicits Potent, yet Distinct, Anticancer Effects on Primary Versus Metastatic Tumors.

Melanoma Literature

Publication date: Jun 23, 2018 Methionine dependency describes the characteristic rapid in vitro death of most tumor cells in the absence of methionine. Combining chemotherapy with dietary methionine deprivation (MDD) ... Read more

December 2, 2017December 2, 2017

Targeting methionine with oral recombinant methioninase (o-rMETase) arrests a patient-derived orthotopic xenograft (PDOX) model of BRAF-V600E mutant melanoma: implications for chronic clinical cancer therapy and prevention.

Melanoma Literature

Publication date: Nov 30, -0001 The elevated methionine (MET) use by cancer cells is termed MET dependence and may be the only known general metabolic defect in cancer. Targeting MET ... Read more

March 22, 2019March 22, 2019

More than an “inverted-U”? An exploratory study of the association between the catechol-o-methyltransferase gene polymorphism and executive functions in Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Oct 29, 2018 Executive dysfunction is common in Parkinson’s disease (PD) patients. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been proposed to affect executive functions (EFs) in the prefrontal ... Read more

March 21, 2019March 21, 2019

Apolipoprotein profiling as a personalized approach to the diagnosis and treatment of dyslipidaemia.

Precision Medicine Literature

Publication date: Mar 19, 2019 An elevated low-density lipoprotein cholesterol concentration is a classical risk factor for cardiovascular disease. This has led to pharmacotherapy in patients with atherosclerotic heart disease ... Read more

March 20, 2019March 20, 2019

A systematic review of the association between fatigue and cognition in chronic noncommunicable diseases.

Multiple Sclerosis Literature

Publication date: Mar 18, 2019 Fatigue is one of the most common symptoms associated with chronic noncommunicable diseases, and it may also increase cognitive impairment. However, associations between fatigue and ... Read more

March 16, 2019March 16, 2019

Evaluation of Two Dosing Regimens for Nivolumab in Combination With Ipilimumab in Patients With Advanced Melanoma

Melanoma News

Publication date: Mar 16, 2019 At a minimum follow-up of 12 months, incidence of treatment-related grade 3 to 5 AEs was 34% with NIVO3+IPI1 versus 48% with NIVO1+IPI3 (P=. 006). ... Read more

March 15, 2019March 15, 2019

Brexit Could Have Real Effects for UK Rare Disease Patients, Experts Warn

Huntington's Disease News

Publication date: Mar 14, 2019 This post was originally published on this site Madeline Collin, a 24-year-old activist with Gaucher disease, worries that patients like her will suffer deeply if ... Read more