Search Results for: Methyl

December 1, 2019December 1, 2019

Methylprednisolone Does Not Reduce Acute Postoperative Pain After Cardiac Surgery: Subanalysis of a Randomized Clinical Trial.

Opioids Literature

Publication date: Dec 01, 2019 Pain after cardiac surgery is largely treated with opioids, but their poor safety profile makes nonopioid medications attractive as part of multimodal pathways. Anti-inflammatory drugs ... Read more

November 22, 2019November 22, 2019

Molecular and immune correlates of TIM-3 (HAVCR2) and galectin 9 (LGALS9) mRNA expression and DNA methylation in melanoma.

Melanoma Literature

Publication date: Nov 20, 2019 The T cell immunoglobulin and mucin-domain containing-3 receptor TIM-3 (also known as hepatitis A virus cellular receptor 2, encoded by HAVCR2) and its ligand galectin ... Read more

November 8, 2019November 8, 2019

HDL-cholesterol elevation associated with fingolimod and dimethyl fumarate therapies in multiple sclerosis.

Multiple Sclerosis Literature

Publication date: May 23, 2019 Patients with Multiple Sclerosis (PwMS) display altered lipoproteins levels and function, which seem to affect disease risk and progress. Whether disease-modifying therapies affect the lipoprotein ... Read more

November 2, 2019November 2, 2019

Cannabidiol Regulates Gene Expression in Encephalitogenic T cells Using Histone Methylation and noncoding RNA during Experimental Autoimmune Encephalomyelitis.

Multiple Sclerosis Literature

Publication date: Oct 31, 2019 Cannabidiol (CBD) has been shown by our laboratory to attenuate experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). In this study, we ... Read more

October 25, 2019October 25, 2019

Anti-John Cunningham virus antibody index levels in multiple sclerosis patients treated with rituximab, fingolimod, and dimethyl fumarate.

Multiple Sclerosis Literature

Publication date: Jan 08, 2019 Progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease caused by the John Cunningham virus (JCV), can occur as a complication of treatment with rituximab, ... Read more

October 25, 2019October 25, 2019

Anti-John Cunningham virus antibody index levels in multiple sclerosis patients treated with rituximab, fingolimod, and dimethyl fumarate.

Multiple Sclerosis Literature

October 23, 2019October 23, 2019

Differentially Methylated Super-Enhancers Regulate Target Gene Expression in Human Cancer.

Melanoma Literature

Publication date: Oct 21, 2019 Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to ... Read more

October 12, 2019October 12, 2019

DNA hypermethylation is associated with invasive phenotype of malignant melanoma.

Melanoma Literature

Publication date: Oct 11, 2019 Tumour cell invasion is one of the key processes during cancer progression, leading to life-threatening metastatic lesions in melanoma. As methylation of cancer-related genes plays ... Read more

September 21, 2019September 21, 2019

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load.

Melanoma Literature

Publication date: Sep 19, 2019 Mitotic cell division increases tumour mutation burden and copy number load, predictive markers of the clinical benefit of immunotherapy. Cell division correlates also with genomic ... Read more

August 16, 2019August 16, 2019

Methylwogonin exerts anticancer effects in A375 human malignant melanoma cells through apoptosis induction, DNA damage, cell invasion inhibition and downregulation of the mTOR/PI3K/Akt signalling pathway.

Melanoma Literature

Publication date: Jul 01, 2019 The main purpose of the present research was to study the anticancer effects of methylwogonin in A375 human malignant melanoma cells by evaluating its effects ... Read more