Search Results for: Methyl

March 28, 2020March 28, 2020

Sulforaphane and iberin are potent epigenetic modulators of histone acetylation and methylation in malignant melanoma.

Melanoma Literature

Publication date: Mar 25, 2020 Growing evidence supports that isothiocyanates exert a wide range of bioactivities amongst of which is their capacity to interact with the epigenetic machinery in various ... Read more

March 28, 2020

DNA Methylation in Neurodegenerative and Cerebrovascular Disorders.

Parkinson's Disease Literature

Publication date: Mar 23, 2020 DNA methylation is an epigenetic mechanism by which methyl groups are added to DNA, playing a crucial role in gene expression regulation. The aim of ... Read more

March 21, 2020

Fingolimod and Dimethyl-Fumarate-Derived Lymphopenia is not Associated with Short-Term Treatment Response and Risk of Infections in a Real-Life MS Population.

Multiple Sclerosis Literature

Publication date: Mar 19, 2020 The association between treatment-related lymphopenia in multiple sclerosis, drug efficacy and the risk of infections is not yet fully understood. The objective of this study ... Read more

March 18, 2020March 18, 2020

L-Methylfolate: Augmenting Agent May Contribute to Agitation and Mania

Major Depressive Disorder News

Publication date: Mar 18, 2020 L-methylfolate is commonly presented as a safe augmenting agent to patients with antidepressant non-response in unipolar depression with virtually no side effects. This article discusses ... Read more

March 15, 2020March 15, 2020

Enhanced cognitive performance in experimental autoimmune encephalomyelitis mice treated with dimethyl fumarate after the appearance of disease symptoms.

Multiple Sclerosis Literature

Publication date: Mar 15, 2020 In multiple sclerosis (MS), cognitive dysfunction is common but difficult to treat. We analyzed the impact of dimethyl fumarate, an MS drug with neuroprotective properties, ... Read more

March 13, 2020March 13, 2020

Lifetime Ultraviolet Radiation Exposure and DNA Methylation in Blood Leukocytes: The Norwegian Women and Cancer Study.

Melanoma Literature

Publication date: Mar 11, 2020 Ultraviolet radiation (UVR) exposure is a leading cause of skin cancers and an ubiquitous environmental exposure. However, the molecular mechanisms relating UVR exposure to melanoma ... Read more

March 10, 2020March 10, 2020

Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma.

Melanoma Literature

Publication date: Mar 09, 2020 The presence of immune cells in the tumor microenvironment has been associated with response to immunotherapies across several cancer types, including melanoma. Despite its therapeutic ... Read more

March 9, 2020March 9, 2020

Genome-wide analysis of constitutional DNA methylation in familial melanoma.

Melanoma Literature

Publication date: Mar 06, 2020 Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members ... Read more

March 1, 2020

Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.

Opioids Literature

Publication date: Mar 01, 2020 Management of moderate to severe pain by clinically used opioid analgesics is associated with a plethora of side effects. Despite many efforts have been dedicated ... Read more

February 20, 2020February 20, 2020

Nursing Management of Gastrointestinal Adverse Events Associated With Delayed-Release Dimethyl Fumarate: A Global Delphi Approach.

Multiple Sclerosis Literature

Publication date: Feb 14, 2020 Gastrointestinal (GI) adverse events (AEs) are commonly encountered with delayed-release dimethyl fumarate (DMF), an approved treatment for relapsing multiple sclerosis (MS). Two hundred thirty-nine MS ... Read more