Search Results for: Mice

Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.

Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.

Major Depressive Disorder Literature
Publication date: Sep 03, 2026 Major depressive disorder (MDD) is increasingly recognized as involving both neuroinflammatory alterations and synaptic pathology. While (2R,6R)-hydroxynorketamine (HNK) exerts rapid antidepressant effects via synaptic modulation, ... Read more