Search Results for: Mitochondria

June 19, 2019June 19, 2019

Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF mutation bearing metastatic melanoma cells.

Melanoma Literature

Publication date: Jun 18, 2019 Treatment with vemurafenib, a potent and selective inhibitor of mitogen-activated protein kinase signaling downstream of the BRAF oncogene, elicits dramatic clinical responses in patients with ... Read more

June 17, 2019June 17, 2019

Bullfrog oil (Rana catesbeiana Shaw) induces apoptosis, in A2058 human melanoma cells by mitochondrial dysfunction triggered by oxidative stress.

Melanoma Literature

Publication date: Jun 13, 2019 Bullfrog oil, an animal oil extracted from the adipose tissue of Rana catesbeiana Shaw, showed promising cytotoxic activity against melanoma cells and, therefore, has the ... Read more

June 17, 2019June 17, 2019

Role of GTPases in the regulation of mitochondrial dynamics in Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jun 10, 2019 Mitochondrion is a highly dynamic organelle that undergoes frequent fusion and division, and the balance of these opposing processes regulates mitochondrial morphology, distribution, and function. ... Read more

June 13, 2019June 13, 2019

Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.

Melanoma Literature

Publication date: Mar 07, 2019 Obesity is associated with increased incidence and worse prognosis of more than one dozen tumor types; however, the molecular mechanisms for this association remain under ... Read more

June 1, 2019June 1, 2019

From old to new – Repurposing drugs to target mitochondrial energy metabolism in cancer.

Precision Medicine Literature

Publication date: May 27, 2019 Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences ... Read more

May 17, 2019May 17, 2019

Novel proteomic changes in brain mitochondria provide insights into mitochondrial dysfunction in mouse models of Huntington’s disease.

Huntington's Disease Literature

Publication date: Mar 20, 2019 Huntington’s disease (HD) is a progressive ultimately fatal disorder caused by a glutamine-encoding CAG expansion in the huntingtin (HTT) gene that results in degeneration mainly ... Read more

May 17, 2019May 17, 2019

Miro2 is a Parkin receptor for selective removal of damaged mitochondria

Parkinson's Disease News

Publication date: May 17, 2019 Miro2, a mitochondrial subfamily of the Ras GTPases, was shown to sense both the depolarization and the Ca2+ release from mitochondria, acting as a Parkin ... Read more

May 15, 2019May 15, 2019

Targeting mitochondria to protect axons in progressive MS.

Multiple Sclerosis Literature

Publication date: May 10, 2019 Inflammatory demyelinating processes target the neuron, particularly axons and synapses, in multiple sclerosis (MS). There is a gathering body of evidence indicating molecular changes which ... Read more

May 15, 2019May 15, 2019

Mitochondrial Dysfunction and Multiple Sclerosis.

Multiple Sclerosis Literature

Publication date: May 11, 2019 In recent years, several studies have examined the potential associations between mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS), Parkinson’s disease and Alzheimer’s ... Read more

May 4, 2019May 4, 2019

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Multiple Sclerosis Literature

Publication date: May 01, 2019 Interference with immune cell proliferation represents a successful treatment strategy in T cell-mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis (MS). One prominent ... Read more