Search Results for: Mitochondria

December 6, 2019December 6, 2019

PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin.

Publication date: Dec 03, 2019 Dysregulation of mitophagy, whereby damaged mitochondria are labeled for degradation by the mitochondrial kinase PINK1 and E3 ubiquitin ligase Parkin with phosphorylated ubiquitin chains (p-S65 ... Read more

December 6, 2019December 6, 2019

Regulatory effects associated with changes in intracellular potassium level in susceptibility to mitochondrial depolarization and excitotoxicity.

Huntington's Disease Literature

Publication date: Dec 02, 2019 Excitotoxicity has been believed to be one of the causes of neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease. So far, much research has ... Read more

November 30, 2019November 30, 2019

Treadmill exercise rescues mitochondrial function and motor behavior in the CAG knock-in mouse model of Huntington’s disease.

Huntington's Disease Literature

Publication date: Nov 26, 2019 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by polyglutamine (CAG) expansion in the Huntingtin (HTT) gene. The CAG knock-in (KI) mouse model ... Read more

November 23, 2019November 23, 2019

Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington’s disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction.

Huntington's Disease Literature

Publication date: Feb 21, 2019 The aim of the present study was to evaluate the solanesol (SNL)-mediated coenzyme-Q10 restoration to ameliorate 3-nitropropionic (3-NP)-induced behavioral, biochemical, and histological changes which resemble ... Read more

November 22, 2019November 22, 2019

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington’s disease mice.

Huntington's Disease Literature

Publication date: Nov 18, 2019 Abnormal protein homeostasis (proteostasis), dysfunctional mitochondria, and aberrant redox signalling are often associated in neurodegenerative disorders, such as Huntington’s (HD), Alzheimer’s and Parkinson’s diseases. It ... Read more

November 8, 2019November 8, 2019

Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells.

Multiple Sclerosis Literature

Publication date: Nov 05, 2019 Recent data highlight the important roles of the gut microbiome, gut permeability, and alterations in mitochondria functioning in the pathophysiology of multiple sclerosis (MS). This ... Read more

November 5, 2019November 5, 2019

Glial mitochondrial function and dysfunction in health and neurodegeneration.

Huntington's Disease Literature

Publication date: Oct 31, 2019 Mitochondria play essential metabolic roles in neural cells. Mitochondrial dysfunction has profound effects on the brain. In primary mitochondrial diseases, mutations that impair specific oxidative ... Read more

November 5, 2019November 5, 2019

Mitochondrial complex IV is lost in neurons in the cuprizone mouse model.

Multiple Sclerosis Literature

Publication date: Oct 31, 2019 Cuprizone administration in mice leads to oligodendrocyte death and demyelination. The effect is thought to reflect copper-chelation that leads to inhibition of complex IV of ... Read more

October 24, 2019October 24, 2019

GABA-A receptor and mitochondrial TSPO signaling act in parallel to regulate melanocyte stem cell quiescence in larval zebrafish.

Melanoma Literature

Publication date: Oct 23, 2019 Tissue regeneration and homeostasis often require recruitment of undifferentiated precursors (adult stem cells; ASCs). While many ASCs continuously proliferate throughout the lifetime of an organism, ... Read more

October 5, 2019October 5, 2019

MFF REGULATION OF MITOCHONDRIAL CELL DEATH IS A THERAPEUTIC TARGET IN CANCER.

Melanoma Literature

Publication date: Oct 03, 2019 The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of Mitochondrial ... Read more