Search Results for: Mitochondria

September 7, 2019September 7, 2019

Neuroprotective effects of cordycepin with anti-apoptosis mechanism based on mitochondrial pathway in rotenone-induced parkinsonism rat model.

Publication date: Sep 05, 2019 Cordycepin (Cor), one of the major bioactive components of traditional Chinese medicine Cordyceps militaris, has been used in clinical practice for several years. However, the ... Read more

September 7, 2019September 7, 2019

Insights from Drosophila on mitochondrial complex I.

Parkinson's Disease Literature

Publication date: Sep 04, 2019 NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI), is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is localized ... Read more

August 29, 2019August 29, 2019

Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders.

Huntington's Disease Literature

Publication date: Aug 28, 2019 The endoplasmic reticulum (ER) and mitochondria are fundamental organelles highly interconnected with a specialized set of proteins in cells. ER-mitochondrial interconnections form specific microdomains, called ... Read more

August 27, 2019August 27, 2019

Vitamin K2 in People with Parkinson’s with Mitochondrial Mutation

Parkinson's Disease News

Publication date: Aug 26, 2019 Over the next three years the Parkinson’s Foundation will invest more than $50 million to Parkinson’s disease (PD) research and clinical care. Jannik Prasuhn, MD, ... Read more

August 24, 2019August 24, 2019

A novel mitochondrial inhibitor blocks MAPK pathway and overcomes MAPK inhibitor-resistance in melanoma.

Melanoma Literature

Publication date: Aug 22, 2019 To determine if inhibition of mitochondrial oxidative phosphorylation (OxPhos) is an effective strategy against MAPK pathway inhibitor (MAPKi)-resistant BRAF-mutant melanomas. The anti-melanoma activity of IACS-010759 ... Read more

August 23, 2019August 23, 2019

Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells.

Melanoma Literature

Publication date: Aug 20, 2019 Cellular senescence is an endpoint of chemotherapy, and targeted therapies in melanoma and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing ... Read more

August 23, 2019August 23, 2019

Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin.

Huntington's Disease Literature

Publication date: Aug 21, 2019 In the present study, we investigated whether mutant huntingtin (mHTT) impairs mitochondrial functions in human striatal neurons derived from induced pluripotent stem cells (iPSCs). Striatal ... Read more

August 17, 2019August 17, 2019

Mutant Huntingtin Fails to Directly Impair Brain Mitochondria.

Huntington's Disease Literature

Publication date: Aug 16, 2019 Although the mechanisms by which mutant huntingtin (mHtt) results in Huntington’s disease (HD) remain unclear, mHtt-induced mitochondrial defects were implicated in HD pathogenesis. The effect ... Read more

August 15, 2019August 15, 2019

MIM1 induces COLO829 melanoma cells death trough mitochondrial membrane breakdown, GSH depletion and DNA damage.

Melanoma Literature

Publication date: Aug 14, 2019 Malignant melanoma is a high aggressive malignancy in humans and causes 60-80% of deaths from skin cancer. Defect in an intrinsic pathway of apoptosis via ... Read more

August 9, 2019August 9, 2019

Exploring Mitochondria Mediated Intrinsic Apoptosis by New Phytochemical Entities: An Explicit Observation of Cytochrome c Dynamics on Lung and Melanoma Cancer Cells.

Melanoma Literature

Publication date: Aug 08, 2019 Hydnocarpin (Hy) is a flavonoid isolated and purified from the seeds of Hydnocarpus wightiana Blume. Herein, we have originated a built-in semi-synthetic modification on Hy ... Read more