Search Results for: Models

May 11, 2025

A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7

Melanoma News

Publication date: May 09, 2025 The B16 murine melanoma cell lines are considered the gold standard for testing melanoma immunotherapies due to low treatment success rates. However, the clinical relevance ... Read more

May 11, 2025

Using machine learning models to predict the impact of template mismatches on polymerase chain reaction assay performance.

Coronavirus Literature

Publication date: May 09, 2025 Molecular assays are critical tools for the diagnosis of infectious diseases. These assays have been extremely valuable during the COVID pandemic, used to guide both ... Read more

May 10, 2025

Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy.

Major Depressive Disorder Literature

Publication date: May 09, 2025 Major Depressive Disorder (MDD) is a prevalent psychiatric disorder with a profound impact on global health, necessitating a deeper understanding of its pathophysiology. This review ... Read more

May 10, 2025May 10, 2025

Systematic review and meta-analysis of no show or non-attendance rates among telehealth and in-person models of care.

Coronavirus Literature

Publication date: May 09, 2025 Comparisons of no-show rates between virtual and in-person models of care are commonly reported during evaluation, indicating how coveted improvements in attendance are to health ... Read more

May 10, 2025

Rationale and design of the TeleClinical Care Cardiac (TCC-Cardiac) trial: A pragmatic randomized trial of adjunctive virtual models of care in the secondary prevention of cardiovascular events.

Coronavirus Literature

Publication date: Aug 01, 2025 Digital health interventions have potential to improve outcomes in high risk cardiac patients through remote monitoring and patient education but introduce accessibility issues among patients ... Read more

May 9, 2025

Delivering a new generation of translational animal models for depression research.

Major Depressive Disorder Literature

Publication date: Jun 01, 2025 Early animal models of depression focused on developing methods that could predict treatment efficacy and were validated based on pharmacological responses to known antidepressants. As ... Read more

May 7, 2025

Gene-modified animal models of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: May 04, 2025 Parkinson’s disease (PD) is a neurodegenerative disorder that commonly occurs in older individuals and clinically manifests as resting tremors, bradykinesia, muscle stiffness, and impaired postural ... Read more

May 7, 2025

Particulate matter 2.5 (PM) – associated cognitive impairment and morbidity in humans and animal models: a systematic review.

Autism Literature

Publication date: May 19, 2025 Particulate matter with an aerodynamic diameter of less than 2. 5 um (PM) is one of the criteria air pollutants that (1) serve as an essential ... Read more

May 7, 2025

Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial Disfunction

Autism News

Publication date: May 05, 2025 Autism Spectrum Disorder (ASD) presents profound clinical and etiological heterogeneity, complicating the identification of core pathophysiological mechanisms. Single-cell RNA sequencing (scRNA-seq) offers cellular resolution but ... Read more

May 6, 2025

Neuroprotective propensity of N-(5-chloro-2-hydroxyphenyl)-2-(morpholin-4-yl-methyl) benzamide, an inventive calcineurin inhibitor, in biological models of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jun 01, 2025 The current work initially focused on the custom synthesis of ILB-162, an innovative calcineurin inhibitor, known chemically as N-(5-chloro-2-hydroxyphenyl)-2-(morpholin-4-yl-methyl) benzamide to get a yield of ... Read more