Publication date: Jul 03, 2019 There is unmet need to design an analgesic with fewer side effects for severe pain management. Although traditional opioids are the most effective painkillers, they ... Read more

Publication date: Jul 01, 2019 Opioids are among the most effective and widely prescribed medications for the treatment of pain following spinal cord injury (SCI). Spinally-injured patients receive opioids within ... Read more

Publication date: Jun 27, 2019 Opioids are highly effective analgesics, however their therapeutic use is limited by adverse effects that include respiratory depression, dependence, and tolerance. Inflammation has been implicated ... Read more

Publication date: Jun 12, 2019 The incremental dose of opioids used in chronic pain management often leads to a reduced opioid analgesic effect, opioid misuse, and addiction. Central dopamine (DA) ... Read more

Publication date: Jun 03, 2019 Persistent use of prescription opioids beyond the period of surgical recovery is a large part of a public health problem linked to the current opioid ... Read more

Publication date: May 28, 2019 As the opioid addiction crisis reaches epidemic levels, the identification of opioid analgesics that lack abuse potential may provide a path to safer treatment of ... Read more

Publication date: May 20, 2019 Morphine is one of the most potent analgesics used in medicine and it’s long-term use is associated with the risk of the state of dependence. ... Read more

Publication date: May 15, 2019 A secondary consequence of spinal cord injury (SCI) is debilitating chronic neuropathic pain, which is commonly morphine resistant and inadequately managed by current treatment options. ... Read more