Search Results for: NF-kappa B

October 11, 2024October 11, 2024

MiR-204-5p overexpression abrogates Dacarbazine-induced senescence in melanoma cells in vivo MiR-204-5p abrogates senescence.

Melanoma Literature

Publication date: Feb 01, 2025 Cancer cell drug resistance hinders significantly therapeutic modalities in oncology. Dacarbazine is chemotherapeutic agent traditionally used for melanoma treatment although it’s effectiveness insufficient. In the ... Read more

October 10, 2024October 10, 2024

Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway.

Parkinson's Disease Literature

Publication date: Aug 18, 2024 The exploration of novel natural products for Parkinson’s disease (PD) is a focus of current research, as there are no definitive drugs to cure or ... Read more

October 2, 2024October 2, 2024

Comparative effect of atorvastatin and risperidone on modulation of TLR4/NF-κB/NOX-2 in a rat model of valproic acid-induced autism.

Autism Literature

Publication date: Sep 30, 2024 Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that is significantly increasing, resulting in severe distress. The approved treatment for ASD only partially improves ... Read more

September 29, 2024September 29, 2024

RNA-Seq analysis of human heart tissue reveals SARS-CoV-2 infection and inappropriate activation of the TNF-NF-κB pathway in cardiomyocytes.

Coronavirus Literature

Publication date: Sep 27, 2024 The negative impact of SARS-CoV-2 virus infection on cardiovascular disease (CVD) patients is well established. This research article explores the cellular pathways involved in underlying ... Read more

September 29, 2024September 29, 2024

RNA-Seq analysis of human heart tissue reveals SARS-CoV-2 infection and inappropriate activation of the TNF-NF-κB pathway in cardiomyocytes.

Coronavirus Literature

September 17, 2024September 17, 2024

Anti-pneumoconiosis effect of schisantherin A in PMA-induced A549 cells and SiO/TiOnanoparticles-induced acute pulmonary injury in mice.

Coronavirus Literature

Publication date: Nov 05, 2024 There has been significant global interest in respiratory health driven by the coronavirus disease (COVID-19) and severe environmental pollution. This study explored the potential of ... Read more

September 12, 2024September 12, 2024

Zinc attenuates monocrotaline-induced pulmonary hypertension in rats through upregulation of A20.

Coronavirus Literature

Publication date: Oct 01, 2024 Pulmonary hypertension (PH) is characterized by excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), in which inflammatory signaling caused by activation of ... Read more

September 11, 2024September 11, 2024

REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage.

Parkinson's Disease Literature

Publication date: Sep 10, 2024 Parkinson’s disease (PD) is characterized by astrocyte activation and disruptions in circadian rhythm. Within the astrocyte population, two distinct reactive states exist: A1 and A2. ... Read more

September 2, 2024September 2, 2024

Cytokines from SARS-CoV-2 Spike-Activated Macrophages Hinder Proliferation and Cause Cell Dysfunction in Endothelial Cells.

Coronavirus Literature

Publication date: Jul 30, 2024 Endothelial dysfunction plays a central role in the severity of COVID-19, since the respiratory, thrombotic and myocardial complications of the disease are closely linked to ... Read more

September 2, 2024September 2, 2024

Cytokines from SARS-CoV-2 Spike-Activated Macrophages Hinder Proliferation and Cause Cell Dysfunction in Endothelial Cells.

Coronavirus Literature