Search Results for: NMDA receptor

June 28, 2020June 28, 2020

Brain NMDA Receptors in Schizophrenia and Depression.

Publication date: Jun 23, 2020 N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP), dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia, both in animals and humans. ... Read more

June 23, 2020June 23, 2020

“NMDA receptor spectrum disorder” in the differential diagnosis of demyelinating disorders of the CNS: optic neuritis and myelitis.

Multiple Sclerosis Literature

Publication date: Jun 20, 2020 The aim of this study was to investigate the frequency of anti-N-methyl-D-aspartate receptor (anti-NMDAR) antibody positivity in patients presenting with transverse myelitis (TM) and/or optic ... Read more

June 12, 2020June 12, 2020

NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity

Major Depressive Disorder News

Publication date: Jun 10, 2020 NMDA receptors (NMDAR) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission in the nervous system. A central feature of NMDAR ... Read more

June 5, 2020June 5, 2020

NMDA receptors control cortical axonal projections via EPHRIN-B/EPHB signaling

Major Depressive Disorder News

Publication date: Jun 03, 2020 Callosal projections from primary somatosensory cortex (S1) are key for processing somatosensory inputs and integrating sensory-motor information. How the callosal innervation pattern in S1 is ... Read more

May 29, 2020May 29, 2020

Anti-NMDA Receptor Encephalitis in a Psychiatric Covid-19 Patient: a Case Report.

Coronavirus Literature

Publication date: May 23, 2020 Concepts Keywords Encephalitis Branches of biology NMDA Receptor Glutamate Medical specialties RTT Autoimmune diseases Encephalitis NMDA receptor N-Methyl-D-aspartic acid Autoimmune encephalitis Semantics Type Source Name ... Read more

May 15, 2020May 15, 2020

Ketamine and nitrous oxide: The evolution of NMDA receptor antagonists as antidepressant agents.

Major Depressive Disorder Literature

Publication date: May 15, 2020 N-methyl-d-aspartate receptor (NMDAR) antagonists, including ketamine and nitrous oxide, are currently intensely studied as rapid-acting antidepressant agents. Interestingly, both of these compounds are also drugs ... Read more

April 23, 2020April 23, 2020

Steroid hormone secretion after stimulation of mineralocorticoid and NMDA receptors and cardiovascular risk in patients with depression.

Major Depressive Disorder Literature

Publication date: Apr 20, 2020 Major depressive disorder (MDD) is associated with altered mineralocorticoid receptor (MR) and glucocorticoid receptor function, and disturbed glutamatergic signaling. Both systems are closely intertwined and ... Read more

March 9, 2020March 9, 2020

From bedside-to-bench: What disease-associated variants are teaching us about the NMDA receptor.

Precision Medicine Literature

Publication date: Mar 07, 2020 NMDA receptors (NMDARs) are glutamate-gated ion channels that contribute to nearly all brain processes. Not surprisingly then, genetic variations in the genes encoding NMDAR subunits ... Read more

February 28, 2020February 28, 2020

A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability.

Huntington's Disease Literature

Publication date: Feb 27, 2020 Calcium (Ca)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca-permeable if they lack the GluA2 ... Read more

February 16, 2020

Less NMDA Receptor Binding in Dorsolateral Prefrontal Cortex and Anterior Cingulate Cortex Associated with Reported Early Life Adversity but Not Suicide.

Major Depressive Disorder Literature

Publication date: Feb 15, 2020 Glutamate, an excitatory neurotransmitter binding to three classes of receptors including the N-methyl, D-aspartate (NMDA) receptor. NMDA receptor binding is lower in major depression (MDD) ... Read more