Publication date: Dec 05, 2019 Using midbrain cultures, we previously demonstrated that the noble gas xenon is robustly protective for dopamine (DA) neurons exposed to L-trans-pyrrolidine-2,4-dicarboxylate (PDC), an inhibitor of ... Read more

Publication date: Nov 18, 2019 Following Braak’s hypothesis on the infectious pathogenesis of sporadic Parkinson’s disease (sPD), several bacteria and viruses have been investigated as likely culprits. Recent research has ... Read more

Publication date: Mar 22, 2019 The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an ... Read more

Publication date: Oct 24, 2019 Parkinson’s disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are ... Read more

Publication date: Dec 05, 2019 Mutations in LRRK2 and GBA1 are common genetic risk factors for Parkinson’s disease (PD) and major efforts are underway to develop new therapeutics that target ... Read more

Publication date: Nov 28, 2019 BRCA1-BRCA2-containing complex subunit 3 (BRCC3), a Lys-63-specific deubiquitinase, is a member of the JAMM/MPN family of zinc metalloproteases. BRCC3 have been shown to promote the ... Read more