Search Results for: Neuron

September 17, 2019September 17, 2019

Silver staining (Campbell-Switzer) of neuronal α-synuclein assemblies induced by multiple system atrophy and Parkinson’s disease brain extracts in transgenic mice.

Publication date: Sep 16, 2019 Synucleinopathies share filamentous α-synuclein assemblies in nerve cells and glial cells. We ... Read more

September 15, 2019

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher’s disease iPSC-neuronal cells.

Parkinson's Disease Literature

Publication date: Sep 13, 2019 Bi-allelic GBA1 mutations cause Gaucher’s disease (GD), the most common lysosomal storage disorder (LSD). Neuronopathic manifestations in GD include neurodegeneration, which can be severe and ... Read more

September 15, 2019

Salidroside Protects Dopaminergic Neurons by Regulating the Mitochondrial MEF2D-ND6 Pathway in the MPTP/MPP -Induced Model of Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Sep 14, 2019 Mitochondrial complex I damage and oxidative stress play critical roles in the degeneration of dopaminergic (DA) neurons during the progression of Parkinson’s disease (PD). Our ... Read more

September 14, 2019September 14, 2019

#ECTRIMS2019 – Eliminating SARM1 Protects Neurons in Mouse Model of MS

Multiple Sclerosis News

Publication date: Sep 13, 2019 This post was originally published on this site Eliminating SARM1, an enzyme that plays a key role in nerve cell degeneration, protects neurons in mice ... Read more

September 12, 2019September 12, 2019

FGF2 and dual agonist of NCAM and FGF receptor 1, Enreptin, rescue neurite outgrowth loss in hippocampal neurons expressing mutated huntingtin proteins.

Huntington's Disease Literature

Publication date: Sep 09, 2019 In the present study, we developed an in vitro model of Huntington disease (HD) by transfecting primary rat hippocampal neurons with plasmids coding for m-htt ... Read more

September 12, 2019September 12, 2019

CTIP2-Regulated Reduction in PKA-Dependent DARPP32 Phosphorylation in Human Medium Spiny Neurons: Implications for Huntington Disease.

Huntington's Disease Literature

Publication date: Sep 10, 2019 The mechanisms underlying the selective degeneration of medium spiny neurons (MSNs) in Huntington disease (HD) remain largely unknown. CTIP2, a transcription factor expressed by all ... Read more

September 12, 2019September 12, 2019

RIP1/RIP3/MLKL mediates dopaminergic neuron necroptosis in a mouse model of Parkinson disease.

Parkinson's Disease Literature

Publication date: Sep 10, 2019 Parkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by severe neuronal loss. Necroptosis, or programmed cell necrosis, is mediated by ... Read more

September 12, 2019September 12, 2019

Drosophila Alpha-ketoglutarate-dependent dioxygenase AlkB is involved in repair from neuronal disorders induced by ultraviolet damage.

Parkinson's Disease Literature

Publication date: Sep 09, 2019 AlkB family proteins are enzymes that repair alkylated DNA and RNA by oxidative demethylation. Nine homologs have been identified and characterized in mammals. ALKBH1 is ... Read more

September 11, 2019September 11, 2019

Prevail Therapeutics Provides Program Update on PR001 in Parkinson’s Disease with GBA1 Mutations and Neuronopathic Gaucher Disease

Parkinson's Disease News

Publication date: Sep 11, 2019 NEW YORK, Sept. 10, 2019 (GLOBE NEWSWIRE) — Prevail Therapeutics Inc. (NASDAQ: PRVL), a biotechnology company developing AAV-based gene therapies for patients with neurodegenerative disorders, ... Read more

September 9, 2019

Antioxidant and anti-inflammatory effects of Dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Sep 05, 2019 Emerging evidence has demonstrated that the integrity and the function of blood-brain barrier (BBB) are gradually impaired in the processes of aging and nervous system ... Read more