Search Results for: Nucleotides

July 15, 2020July 15, 2020

Therapeutic antisense oligonucleotides for movement disorders.

Publication date: Jul 13, 2020 Movement disorders are a group of neurological conditions characterized by abnormalities of movement and posture. They are broadly divided into akinetic and hyperkinetic syndromes. Until ... Read more

May 20, 2020May 20, 2020

CpG Oligonucleotides Protect Mice From Alphavirus Encephalitis: Role of NK Cells, Interferons, and TNF.

Chikungunya Literature

Publication date: Nov 08, 2019 Arboviruses including alphavirus are responsible for most emerging infectious diseases worldwide. Recent outbreaks of chikungunya virus serve as a stark reminder to their pathogenic potential. ... Read more

May 19, 2020May 19, 2020

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides.

Coronavirus Literature

Publication date: Mar 27, 2020 For decades, nucleosides and nucleotides have formed the cornerstone of antiviral, antiparasitic and anticancer therapeutics and have been used as tools in exploring nucleic acid ... Read more

April 24, 2020April 24, 2020

CpG Dinucleotides Inhibit HIV-1 Replication through Zinc Finger Antiviral Protein (ZAP)-Dependent and -Independent Mechanisms.

Coronavirus Literature

Publication date: Feb 28, 2020 CpG dinucleotides are suppressed in the genomes of many vertebrate RNA viruses, including HIV-1. The cellular antiviral protein ZAP (zinc finger antiviral protein) binds CpGs ... Read more

April 18, 2020April 18, 2020

Oligonucleotides and the COVID-19 Pandemic: A Perspective.

Coronavirus Literature

Publication date: Apr 13, 2020 The present global health emergency involving the emergence and rapid spread of a novel coronavirus has prompted the world scientific community to consider how it ... Read more

August 4, 2020August 4, 2020

The emerging role of lncRNAs in multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Jul 29, 2020 Multiple sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) with various clinical manifestations. The characteristic of MS is ... Read more

August 3, 2020August 4, 2020

Supersensitive Multifluorophore RNA-FISH for Early Virus Detection and Flow-FISH by Using Click Chemistry.

Coronavirus Discovery

Publication date: Aug 03, 2020 The reliable detection of transcription events through the quantification of the corresponding mRNA is of paramount importance for the diagnostics of infections and diseases. The ... Read more

August 2, 2020August 4, 2020

Correction to: Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Additional Benefit.

Coronavirus Discovery

Publication date: Aug 02, 2020 During the proofing process, the misspelling of “additional” occurred while changing the title of the article. The complete title should be “Remdesivir for Treatment of ... Read more

August 1, 2020August 1, 2020

Therapeutic strategies for Huntington’s disease.

Huntington's Disease Literature

Publication date: Aug 01, 2020 Huntington’s disease is a fatal autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HTT gene, and current therapies focus on symptomatic treatment. ... Read more

July 31, 2020July 31, 2020

Investigation of genomic DNA methylation by UV Resonant Raman spectroscopy.

Melanoma Literature

Publication date: Jul 29, 2020 Cytosine plays a preeminent role in DNA methylation, an epigenetic mechanism that regulates gene expression, the misregulation of which can lead to severe diseases. Several ... Read more