Search Results for: Nucleotides

December 6, 2019December 6, 2019

Selective Targeting of Mutant Huntingtin Using Stereopure Oligonucleotides

Publication date: Dec 05, 2019 Selective Targeting of Mutant Huntingtin Using Stereopure Oligonucleotides as a Potential Therapeutic Approach for Huntington?s Disease – Michael Panzara Scientific Symposium from the American Society ... Read more

October 26, 2019October 26, 2019

Mesenchymal stem cells alleviate AQP-4-dependent glymphatic dysfunction and improve brain distribution of antisense oligonucleotides in BACHD mice.

Huntington's Disease Literature

Publication date: Oct 24, 2019 Huntington’s disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene that results in the production of neurotoxic mutant HTT ... Read more

October 1, 2019October 1, 2019

Antisense oligonucleotides might change the therapeutic landscape for Huntington’s disease.

Huntington's Disease Literature

Publication date: Oct 01, 2019 Paulsen, J.S. and Coffey, C.S. Antisense oligonucleotides might change the therapeutic landscape for Huntington’s disease. 06703. 2019 Lancet Neurol (18):10. Concepts Keywords Lancet The Lancet ... Read more

June 12, 2019June 12, 2019

Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington’s Disease.

Huntington's Disease Literature

Publication date: Jun 11, 2019 Huntington’s disease is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of huntingtin gene (HTT) encoding for a toxic polyglutamine ... Read more

May 18, 2019May 18, 2019

Targeted Oligonucleotides for Treating Neurodegenerative Tandem Repeat Diseases.

Huntington's Disease Literature

Publication date: May 16, 2019 Nucleotide repeat disorders encompass more than 30 diseases, most of which show dominant inheritance, such as Huntington’s disease, spinocerebellar ataxias, and myotonic dystrophies. Yet others, ... Read more

April 20, 2019April 20, 2019

Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs.

Melanoma Literature

Publication date: Apr 17, 2019 Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, ... Read more

April 7, 2018April 7, 2018

Dose-Dependent Lowering of Mutant Huntingtin Using Antisense Oligonucleotides in Huntington Disease Patients.

Huntington's Disease Literature

Publication date: Apr 01, 2018 On December 11 of 2017, Ionis Pharmaceuticals published a press release announcing dose-dependent reductions of mutant huntingtin protein in their HTTRx Phase 1/2a study in ... Read more

December 5, 2019December 5, 2019

Asia-wide genome mapping project reveals insights into Asian ancestry and genetic diversity

Precision Medicine News

Publication date: Dec 05, 2019 IMAGE: (Left to right) NTU Assistant Professor Hie Lim Kim, NTU Professor Stephan Schuster and GenomeAsia 100K Executive Chairman Mahesh Pratapneni, with the analysis of ... Read more

November 26, 2019November 26, 2019

Asuragen Partners with Wave Life Sciences to Develop Companion Diagnostics for Huntington’s Disease

Huntington's Disease News

Publication date: Nov 26, 2019 Asuragen, Inc. , a molecular diagnostics company delivering easy-to-use products for complex testing in genetics and oncology, and Wave Life Sciences, a clinical-stage genetic medicines ... Read more

November 24, 2019November 24, 2019

MiRNA therapeutics based on logic circuits of biological pathways.

Melanoma Literature

Publication date: Nov 22, 2019 In silico experiments, with the aid of computer simulation, speed up the process of in vitro or in vivo experiments. Cancer therapy design is often ... Read more