Search Results for: Nucleotides

January 15, 2021January 15, 2021

Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.

Publication date: Jan 01, 2021 Parkinson’s disease (PD) is the second most common neurodegenerative disease. Pathologically, PD is characterized by the formation of Lewy bodies (LBs) in the brain, which ... Read more

January 15, 2021January 15, 2021

Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease.

Parkinson's Disease Literature

July 15, 2020July 15, 2020

Therapeutic antisense oligonucleotides for movement disorders.

Huntington's Disease Literature

Publication date: Jul 13, 2020 Movement disorders are a group of neurological conditions characterized by abnormalities of movement and posture. They are broadly divided into akinetic and hyperkinetic syndromes. Until ... Read more

December 23, 2020December 23, 2020

De novo small deletion affecting transcription start site of short isoform of AUTS2 gene in a patient with syndromic neurodevelopmental defects.

Autism Literature

Publication date: Dec 21, 2020 Disruption of the autism susceptibility candidate 2 (AUTS2) gene through genomic rearrangements, copy number variations (CNVs), and intragenic deletions and mutations, has been recurrently involved ... Read more

December 14, 2020December 14, 2020

Genetics of Autism | Dr Abha Gupta | Chapel Haven Schleifer & Yale Child Study Center

Autism Media

Publication date: Dec 12, 2020 Concepts Keywords Abha Radiation Adenine Counseling Air Individuals autism Amino Acids Proportion syndrome autism Arizona Advancements autism Autism Gene mutations disorder Autism Spectrum Disorders Important ... Read more

December 5, 2020December 5, 2020

Infectious RNA vaccine protects mice against chikungunya virus infection.

Chikungunya Literature

Publication date: Dec 03, 2020 We describe a novel vaccine platform that can generate protective immunity to chikungunya virus (CHIKV) in C57BL/6J mice after a single immunization by employing an ... Read more

December 4, 2020December 4, 2020

Terahertz Response of Biological Tissue for Diagnostic and Treatment in Personalized Medicine

Precision Medicine News

Publication date: Dec 03, 2020 A spectrometer based on silicon nanosandwiches (SNS) is proposed for problems of personalized medicine. SNS structures exhibit properties of terahertz (THz) emitter and receiver of ... Read more

November 19, 2020November 19, 2020

Developmental dynamics of voltage-gated sodium channel isoform expression in the human and mouse neocortex

Autism News

Publication date: Nov 17, 2020 Objective: Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The ... Read more

November 17, 2020November 17, 2020

Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for Rapid, Accurate, and Affordable Somatic Mutation Detection

Precision Medicine News

Publication date: Nov 15, 2020 Nanopore sequencing is more than 10-fold faster than sequencing-by-synthesis and provides reads that are roughly 100-fold longer. However, nanopore sequencing’s 7.5% intrinsic error rate renders ... Read more

November 15, 2020November 15, 2020

Schizophrenia and autism-associated mutations and disrupted m6A signal by YTHDF1 cause defects in microtubule function and neurodevelopment

Autism News

Publication date: Nov 13, 2020 Building and maintaining neuronal networks and cognitive functions require mRNA localization and regulated protein synthesis in neurons. RNA modification N6-methyl-adenosine (m6A) has recently been shown ... Read more