Search Results for: Oxidative Stress

October 7, 2019October 7, 2019

Apelin-36 Mediates Neuroprotective Effects by Regulating oxidative stress, autophagy and apoptosis in MPTP-induced Parkinson’s Disease model mice.

Publication date: Oct 03, 2019 Parkinson’s disease (PD), a common human neurodegenerative disorder, is characterized by the presence of intraneuronal Lewy bodies composed principally of abnormal aggregated and post-translationally modified ... Read more

September 29, 2019September 29, 2019

Effects of Sulfated Fucans from Laminaria hyperborea Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight.

Melanoma Literature

Publication date: Sep 25, 2019 Sulfated fucans show interesting effects in the treatment of ocular diseases (e.g., age-related macular degeneration), depending on their chemical structure. Here, we compared three purified ... Read more

July 16, 2019July 16, 2019

Towards a comprehensive understanding of the contributions of mitochondrial dysfunction and oxidative stress in the pathogenesis and pathophysiology of Huntington’s disease.

Huntington's Disease Literature

Publication date: Jul 15, 2019 Huntington’s disease (HD) is a rare autosomal dominant disorder affecting the corticostriatal area of the brain. HD is driven by elongated cytosine-adenine-guanine (CAG) repeat (36 ... Read more

June 27, 2019June 27, 2019

The effects of probiotic Saccharomyces boulardii on the mental health, quality of life, fatigue, pain, and indices of inflammation and oxidative stress in patients with multiple sclerosis: study protocol for a double-blind randomized controlled clinical trial.

Multiple Sclerosis Literature

Publication date: Jun 24, 2019 The relationship between gut dysbiosis and inflammatory diseases including multiple sclerosis (MS) is presently recognized as an important health issue. It has been established that ... Read more

June 17, 2019June 17, 2019

Bullfrog oil (Rana catesbeiana Shaw) induces apoptosis, in A2058 human melanoma cells by mitochondrial dysfunction triggered by oxidative stress.

Melanoma Literature

Publication date: Jun 13, 2019 Bullfrog oil, an animal oil extracted from the adipose tissue of Rana catesbeiana Shaw, showed promising cytotoxic activity against melanoma cells and, therefore, has the ... Read more

May 24, 2019May 24, 2019

Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells.

Melanoma Literature

Publication date: May 20, 2019 The newly identified melanoma-associated adaptor ShcD was found to translocate to the nucleus upon hydrogen peroxide treatment. Therefore, the aim of this study was to ... Read more

May 1, 2019May 1, 2019

Mitophagy links oxidative stress conditions and neurodegenerative diseases.

Huntington's Disease Literature

Publication date: May 01, 2019 Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and ... Read more

April 30, 2019April 30, 2019

The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells.

Multiple Sclerosis Literature

Publication date: Apr 26, 2019 Fingolimod is one of the few oral drugs available for the treatment of multiple sclerosis (MS), a chronic, inflammatory, demyelinating and neurodegenerative disease. The mechanism ... Read more

March 9, 2019March 9, 2019

Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/HO in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria.

Huntington's Disease Literature

Publication date: Mar 07, 2019 According to recent findings, the human 2-oxoglutarate dehydrogenase complex (hOGDHc) could be an important source of the reactive oxygen species in the mitochondria and could ... Read more

February 21, 2019February 21, 2019

Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

Tuberculosis Literature

Publication date: Feb 20, 2019 Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the ... Read more