Search Results for: Oxidative Stress

June 15, 2019

Autophagy Stimulation Decreases Dopaminergic Neuronal Death Mediated by Oxidative Stress.

Publication date: Jun 13, 2019 The neurodegenerative process of Parkinson’s disease (PD) involves autophagy impairment and oxidative stress. Therefore, we wanted to determine whether stimulation of autophagy protects dopaminergic cell ... Read more

June 15, 2019June 15, 2019

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.

Parkinson's Disease Literature

Publication date: Jun 13, 2019 Specific neuronal populations display high vulnerability to pathological processes in Parkinson’s disease (PD). The dorsal motor nucleus of the vagus nerve (DMnX) is a primary ... Read more

June 13, 2019June 13, 2019

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Jun 10, 2019 Parkinson’s disease, a chronic, age related neurodegenerative disorder, is characterized by a progressive loss of nigrostriatal dopaminergic neurons. Several studies have proven that the activation ... Read more

May 24, 2019May 24, 2019

Studying the ShcD and ERK interaction under acute oxidative stress conditions in melanoma cells.

Melanoma Literature

Publication date: May 20, 2019 The newly identified melanoma-associated adaptor ShcD was found to translocate to the nucleus upon hydrogen peroxide treatment. Therefore, the aim of this study was to ... Read more

May 1, 2019May 1, 2019

Mitophagy links oxidative stress conditions and neurodegenerative diseases.

Huntington's Disease Literature

Publication date: May 01, 2019 Mitophagy is activated by a number of stimuli, including hypoxia, energy stress, and increased oxidative phosphorylation activity. Mitophagy is associated with oxidative stress conditions and ... Read more

April 30, 2019April 30, 2019

The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells.

Multiple Sclerosis Literature

Publication date: Apr 26, 2019 Fingolimod is one of the few oral drugs available for the treatment of multiple sclerosis (MS), a chronic, inflammatory, demyelinating and neurodegenerative disease. The mechanism ... Read more

March 9, 2019March 9, 2019

Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/HO in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria.

Huntington's Disease Literature

Publication date: Mar 07, 2019 According to recent findings, the human 2-oxoglutarate dehydrogenase complex (hOGDHc) could be an important source of the reactive oxygen species in the mitochondria and could ... Read more

February 21, 2019February 21, 2019

Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

Tuberculosis Literature

Publication date: Feb 20, 2019 Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the ... Read more

January 4, 2019January 4, 2019

Oxidative stress generated by irradiation of a zinc(II) phthalocyanine induces a dual apoptotic and necrotic response in melanoma cells.

Melanoma Literature

Publication date: Jan 02, 2019 Melanoma is an aggressive form of skin carcinoma, highly resistant to traditional therapies. Photodynamic therapy (PDT) is a non-invasive therapeutic procedure that can exert a ... Read more

January 4, 2019January 4, 2019

Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis.

Multiple Sclerosis Literature

Publication date: Dec 27, 2018 Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system (CNS). Neuroinflammation ... Read more