Search Results for: P21

December 9, 2024December 9, 2024

Time-resolved fluorescence studies reveal differences in dynamic motion between main proteases of SARS-CoV-2 and SARS-CoV.

Publication date: Dec 04, 2024 The main protease (M) is an attractive drug target for inhibiting the coronavirus. Lots of research has focused on the static viewpoint of the M, ... Read more

December 8, 2024December 8, 2024

Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington’s disease.

Huntington's Disease Literature

Publication date: Dec 05, 2024 There is a growing consensus that brain development in Huntington’s disease (HD) is abnormal, leading to the idea that HD is not only a neurodegenerative ... Read more

December 3, 2024December 3, 2024

Cellular senescence in acute human infectious disease: a systematic review.

Coronavirus Literature

Publication date: Sep 23, 2024 Acute infectious disease represents a significant cause of mortality and morbidity in elderly individuals admitted to the hospital. In its extreme, it presents as sepsis, ... Read more

December 3, 2024December 3, 2024

Impact of senescence cell signature in patients with non-small cell carcinoma and melanoma receiving PD-L1/PD-1 inhibitors.

Melanoma Literature

Publication date: Dec 01, 2024 Tumor cell senescence plays a crucial role in tumor immunity. We investigated whether the senescent cell signature (SCS) could predict prognosis in non-small cell carcinoma ... Read more

December 3, 2024December 3, 2024

Impact of senescence cell signature in patients with non-small cell carcinoma and melanoma receiving PD-L1/PD-1 inhibitors.

Melanoma Literature

December 3, 2024December 3, 2024

Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells.

Melanoma Literature

Publication date: Dec 15, 2024 Solar radiation is the main source of human exposure to UV rays, which is the major carcinogen in skin cancers by inducing DNA damage. Skin ... Read more

December 3, 2024December 3, 2024

Transcriptional and functional regulation of cell cycle and UV response by PPARβ in human skin epidermal cells.

Melanoma Literature

Publication date: Dec 15, 2024 Solar radiation is the main source of human exposure to UV rays, which is the major carcinogen in skin cancers by inducing DNA damage. Skin ... Read more

December 2, 2024December 2, 2024

Therapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations.

Melanoma Literature

Publication date: Nov 30, 2024 Naringin, a flavanone glycoside found abundantly in citrus fruits, is well-known for its various pharmacological properties, particularly its significant anticancer effects. Research, both in vitro ... Read more

November 16, 2024November 16, 2024

Immunogenicity and safety of DS-5670d, an mRNA-based COVID-19 vaccine targeting omicron XBB.1.5: Results from a phase 3, randomized, active-controlled study in adults and children aged >=12 years

Coronavirus News

Publication date: Nov 14, 2024 Background Many people worldwide have now acquired immune responses against the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) following previous vaccination and/or infection. As a result, national ... Read more

November 14, 2024November 14, 2024

Encapsulation of soybean lunasin and amaranth unsaponifiable matter in liposomes induces cell cycle arrest in an allograft melanoma mouse model.

Melanoma Literature

Publication date: Nov 13, 2024 Melanoma is the most aggressive type of skin cancer and can metastasize during primary tumor formation. This research aimed to determine the relationship between the ... Read more