Publication date: Feb 19, 2020 Parkinson’s disease is a neurodegenerative disorder partly caused by the loss of the dopamine neurons of the nigrostriatal pathway. It is accompanied by motor as ... Read more

Publication date: Feb 20, 2020 Dementia is common in Parkinson’s disease (PD) but measures that track cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises ... Read more

Publication date: Feb 20, 2020 Recent reports highlight regulatory functions of long noncoding RNAs (lncRNAs) in neurodegeneration and aging, but biomedical implications remain limited. Here, we report an rRNA-depletion-based long ... Read more

Publication date: Feb 20, 2020 Improved analytical tools for detailed characterization of synucleins in pre-clinical models of Parkinson’s disease (PD) and related synucleinopathies are needed. Develop a multiple reaction monitoring ... Read more

Publication date: Feb 20, 2020 Sleep disturbances and nocturnal hypokinesia are common in Parkinson’s disease (PD). Recent work using wearable technologies showed fewer nocturnal movements in PD when compared with ... Read more

Publication date: Feb 21, 2020 Parkinson’s disease (PD) is characterized by dopaminergic neuronal loss and the presence of intra-neuronal Lewy body (LB) inclusions with aggregated ?-synuclein (?-Syn) as the major ... Read more

Publication date: Feb 21, 2020 Aim: To explore the optimal route of gold nanoclusters (AuNCs) administration in mice targeting Parkinson’s disease. Materials & methods: Assessing the pharmacokinetic and bioavailability of ... Read more

Publication date: Feb 21, 2020 Neuroinflammation in Parkinson’s disease (PD) is known to play a pivotal role in progression to neuronal degeneration. It has been reported that colony-stimulation factor 1 ... Read more

Publication date: Feb 21, 2020 Objective Recent studies have found that selenium (Se) levels were associated with the risk of Parkinson’s disease (PD), but the results were contradictory. Therefore, this ... Read more

Publication date: Feb 21, 2020 Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively ... Read more