Search Results for: Pharmacological

May 13, 2025May 13, 2025

Pharmacological landscape of endoplasmic reticulum stress: Uncovering therapeutic avenues for metabolic diseases.

Publication date: Jul 05, 2025 The endoplasmic reticulum (ER) plays a fundamental role in maintaining cellular homeostasis by ensuring proper protein folding, lipid metabolism, and calcium regulation. However, disruptions to ... Read more

May 7, 2025

Ivermectin repurposing for COVID-19: pharmacological and bibliometric analysis.

Coronavirus Literature

Publication date: May 06, 2025 Since the onset of the COVID-19 pandemic in March 2020, researchers worldwide have sought effective drugs to prevent and manage SARS-CoV-2 and its spectrum of ... Read more

April 28, 2025

[Non-pharmacological interventions: A new paradigm and opportunities for internists].

Coronavirus Literature

Publication date: Apr 26, 2025 The notion of non-pharmacological interventions (NPI) has been used by healthcare researchers since 1975, and is cited in numerous reports by French, European and international ... Read more

April 25, 2025

Effects of Pharmacological Treatment on Telomere Length and the Expression of Telomerase/Shelterin-Related Genes in Rat Models of Autism.

Autism Literature

Publication date: Apr 24, 2025 Telomeres are increasingly recognized for their potential role in the etiology of autism spectrum disorder (ASD) due to their involvement in cellular aging and telomerase-shelterin ... Read more

April 24, 2025

A network pharmacology-based approach to decipher the pharmacological mechanisms of Salvia officinalis in neurodegenerative disorders.

Huntington's Disease Literature

Publication date: Apr 23, 2025 The present study aimed to assess the pharmacological mechanism of Salvia officinalis in Neurodegenerative disorders using a network pharmacology approach followed by molecular docking analysis. ... Read more

April 23, 2025

Investigation of the Neurobiological Mechanisms Underlying Pathological Rumination and the Pharmacological Effects of Aripiprazole

Major Depressive Disorder News

Publication date: Apr 20, 2025 This randomized, single-blind (assessor-blind) controlled trial aims to investigate the efficacy of aripiprazole as an augmentation strategy for treating pathological rumination in patients with major ... Read more

May 15, 2025

Diagnosis, evaluation & management of cognitive disorders in Parkinson’s disease: A systematic review.

Parkinson's Disease Literature

Publication date: May 12, 2025 There is considerable variability in the diagnosis, evaluation and management of cognitive disorders in Parkinson’s disease (PD) across clinical services. A review of guidelines and ... Read more

May 15, 2025

Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: May 14, 2025 Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein (aSyn) accumulation. Environmental factors play a significant role in PD progression, ... Read more

May 15, 2025

Effects of Ninjin’yoeito and physical exercise on serum corticosterone and hippocampal BDNF/proBDNF and neuroinflammation in post-stroke depression in rats.

Major Depressive Disorder Literature

Publication date: May 13, 2025 Ninjin’yoeito (NYT), a traditional Japanese Kampo medicine, improves the depression and anxiety in humans and animals, rendering it a novel therapeutic option for post-stroke depression ... Read more

May 15, 2025

The PREDEP-SERT study protocol: a 6-month follow-up cohort study of predictors of effectiveness and tolerability of sertraline for depression using Therapeutic Drug Monitoring

Major Depressive Disorder News

Publication date: May 13, 2025 Sertraline is a common first-line pharmacological treatment of Major Depressive Disorder (MDD). There is no established consensus nor clinical guidelines for personalized dose adjustments, which ... Read more