Search Results for: Putamen

May 11, 2018May 11, 2018

Transcriptomic integration of DR and MOR signaling in the rat caudate putamen.

Opioids Literature

Publication date: May 09, 2018 Morphine binding to opioid receptors, mainly to μ opioid receptor (MOR), induces alterations in intracellular pathways essential to the initial development of addiction. The activation ... Read more

May 4, 2018May 4, 2018

Atrophy of the putamen at time of clinical motor onset in Huntington’s disease: a 6-year follow-up study.

Huntington's Disease Literature

Publication date: Sep 20, 2017 Striatal atrophy is detectable many years before the predicted onset of motor symptoms in premanifest Huntington’s disease (HD). However, the extent of these neurodegenerative changes ... Read more

December 4, 2019

Pharmacokinetic evaluation of [F]PR04.MZ for PET/CT imaging and quantification of dopamine transporters in the human brain.

Parkinson's Disease Literature

Publication date: Dec 01, 2019 Dopamine transporters (DAT) modulate pre-synaptic dopamine and physiological functions such as movement and reward. DAT also mirrors disease state in neurological disorders, rendering it an ... Read more

November 25, 2019November 25, 2019

Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.

Huntington's Disease Literature

Publication date: Nov 20, 2019 Vitamin B5 (d-pantothenic acid; pantothenate) is an essential trace nutrient that functions as the obligate precursor of coenzyme A (CoA), through which it plays key ... Read more

November 25, 2019November 25, 2019

Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.

Huntington's Disease Literature

November 22, 2019November 22, 2019

GDNF Gene Therapy for Parkinson’s Disease

Parkinson's Disease News

Publication date: Nov 19, 2019 The objective of this Phase 1b investigation is to evaluate the safety and potential clinical effect of AAV2-GDNF delivered to the putamen in subjects with ... Read more

November 11, 2019November 11, 2019

Longitudinal atrophy characterization of cortical and subcortical gray matter in Huntington’s disease patients.

Huntington's Disease Literature

Publication date: Nov 09, 2019 Huntington’s disease (HD) is an inherited neurodegenerative disease with clinical manifestations that involve motor, cognitive, and psychiatric deficits. Cross-sectional Magnetic Resonance Imaging (MRI) studies have ... Read more

November 8, 2019November 8, 2019

Is the walk ratio a window to the cerebellum in multiple sclerosis? A structural MRI study.

Multiple Sclerosis Literature

Publication date: Nov 06, 2019 Existing research studies have demonstrated a relationship between MRI neuroimaging measures and walking speed in people with multiple sclerosis (PwMS). However, to date there are ... Read more

October 26, 2019October 26, 2019

Transgenic minipig model of Huntington’s disease exhibiting gradually progressing neurodegeneration.

Huntington's Disease Literature

Publication date: Oct 23, 2019 Recently developed therapeutic approaches for the treatment of Huntington’s disease (HD) require pre-clinical testing in large animal models. Minipig is a suitable experimental animal because ... Read more

October 10, 2019October 10, 2019

Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington Disease

Huntington's Disease News

Publication date: Oct 09, 2019 This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a ... Read more