Search Results for: ROS1

June 15, 2019June 15, 2019

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer.

Publication date: Jun 13, 2019 Specific neuronal populations display high vulnerability to pathological processes in Parkinson’s disease (PD). The dorsal motor nucleus of the vagus nerve (DMnX) is a primary ... Read more

June 14, 2019June 14, 2019

Patient Reported Outcomes for Opioid Use Disorder

Opioids News

Publication date: Jun 13, 2019 The goal of the project is to build a clinical data research infrastructure that will begin to enhance capacity to use electronic health record (EHR) ... Read more

June 8, 2019June 8, 2019

A Study to Assess Safety and Efficacy of Relatlimab With Ipilimumab in Participants With Advanced Melanoma Who Progressed on Anti-PD-1 Treatment

Melanoma News

Publication date: Jun 07, 2019 The primary purpose of this study is to characterize the safety, tolerability, and dose-limiting toxicities (DLTs) and to determine the recommended dose of relatlimab in ... Read more

June 8, 2019June 8, 2019

The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.

Parkinson's Disease Literature

Publication date: Jun 23, 2018 The N-formyl peptide receptors (FPRs) have been identified within neuronal tissues and may serve as yet undetermined functions within the nervous system. The FPRs have ... Read more

June 7, 2019June 7, 2019

Circadian Rhythms and Energy Metabolism Reprogramming in Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Jun 04, 2019 Entropy rate is increased by several metabolic and thermodynamic abnormalities in neurodegenerative diseases (NDs). Changes in Gibbs energy, heat production, ionic conductance or intracellular acidity ... Read more

June 6, 2019June 6, 2019

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.

Huntington's Disease Literature

Publication date: Jun 04, 2019 The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose ... Read more

June 6, 2019June 6, 2019

Dr. Thomas Bird

Huntington's Disease Media

Publication date: Jun 05, 2019 Dr. Bird is a clinical neurogeneticist with interests in a wide range of hereditary disorders of the nervous system. In 1974, Dr. Thomas Bird founded ... Read more

June 6, 2019June 6, 2019

Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing.

Precision Medicine Literature

Publication date: Jun 04, 2019 Gastric cancer (GC) is a leading cause of cancer deaths, and an increased number of GC patients adopt to next-generation sequencing (NGS) to identify tumor ... Read more

June 5, 2019June 5, 2019

Teriflunomide real-world evidence: Global differences in the phase 4 Teri-PRO study.

Multiple Sclerosis Literature

Publication date: Jun 01, 2019 The demographics and management of patients with multiple sclerosis (MS) differ across geographical regions, but it is unclear whether/how these differences affect treatment outcomes. The ... Read more

June 4, 2019June 4, 2019

TRPM2 in Cancer.

Melanoma Literature

Publication date: Jun 01, 2019 The TRP ion channel TRPM2 has an essential function in cell survival and protects the viability of a number of cell types after oxidative stress. ... Read more