Search Results for: Race

January 16, 2025January 16, 2025

Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells.

Melanoma Literature

Publication date: Jan 17, 2025 Small extracellular vesicles (sEVs) are nanosized vesicles. Death receptor 5 (DR5) mediates extrinsic apoptosis. We engineer DR5 agonistic single-chain variable fragment (scFv) expression on the ... Read more

January 16, 2025January 16, 2025

Aryl Hydrocarbon Receptor Establishes a Delicate Balance between the Level of the Trace Amine Tryptamine and Monoamine Oxidase Activity in the Brain and Periphery in Health and Conditions such as Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders.

Autism Literature

Publication date: Jan 13, 2025 The purpose of this review was to analyse the literature regarding the correlation between the level of tryptamine, aryl hydrocarbon receptor (AHR) signalling pathway activation, ... Read more

January 13, 2025January 13, 2025

Intranasal delivery of extracellular vesicles: A promising new approach for treating neurological and respiratory disorders.

Coronavirus Literature

Publication date: Jan 10, 2025 Extracellular vesicles (EVs) are membrane vesicles secreted by all types of cells, including bacteria, animals, and plants. These vesicles contain proteins, nucleic acids, and lipids ... Read more

January 13, 2025January 13, 2025

Pandemic changes in U.S. contraceptive use: National survey estimates reveal significant differences by demographic subgroups.

Coronavirus Literature

Publication date: Feb 01, 2025 The COVID-19 pandemic brought multiple simultaneous consequences, with high potential to change fertility-related behaviors. We use nationally representative sex and contraceptive use event history calendar ... Read more

January 13, 2025January 13, 2025

Diagnostic value of extracellular matrix degradation biomarkers in serum from patients with Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jan 15, 2025 Parkinson’s Disease (PD) is a progressive neurodegenerative condition, which is highly heterogeneous upon diagnosis. Brain extracellular matrix (ECM) accounts for 10-20 % of the total ... Read more

January 12, 2025January 12, 2025

In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson’s disease models.

Parkinson's Disease Literature

Publication date: Jan 09, 2025 Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene play an important role in Parkinson’s disease (PD) pathogenesis, and downregulation of LRRK2 has become a ... Read more

January 12, 2025January 12, 2025

Alpha-synuclein inhibits the secretion of extracellular vesicles through disruptions in YKT6 lipidation.

Parkinson's Disease Literature

Publication date: Jan 10, 2025 Parkinson’s disease is characterized by the presence of α-synuclein (α-syn) primarily containing Lewy bodies in neurons. Despite decades of extensive research on α-syn accumulation, its ... Read more

January 12, 2025January 12, 2025

Examining the Dimensionality, Internal Consistency, and Invariance of the Depression, Anxiety, and Stress Scale-21 (DASS-21) Across Age, Race, Ethnicity, and Caretaking Status.

Coronavirus Literature

Publication date: Jan 11, 2025 This study investigates the performance of the Depression, Anxiety, and Stress Scale-21 (DASS-21) across diverse demographic groups during the COVID-19 pandemic. Utilizing a large, generalizable ... Read more

January 10, 2025January 10, 2025

Protocol for investigating intracellular microbial diversity using single-cell RNA-seq in immune cells of SARS-CoV-2-positive and recovered patients.

Coronavirus Literature

Publication date: Jan 08, 2025 Intracellular microorganisms like viruses and bacteria impact immune cell function. However, detection of these microbes is challenging as the majority exist in a non-culturable state. ... Read more

January 9, 2025January 9, 2025

Intracerebroventricular anaerobic dopamine in Parkinson’s disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial.

Parkinson's Disease Literature

Publication date: Jan 07, 2025 Continuous compensation for cerebral dopamine deficiency represents an ideal treatment for Parkinson’s disease. Dopamine does not cross the digestive and blood-brain barriers and is rapidly ... Read more