Search Results for: Rag

March 24, 2025March 24, 2025

Vortioxetine attenuates rotenone-induced enteric neuroinflammation via modulation of the TLR2/S100B/RAGE signaling pathway in a rat model of Parkinson’s disease.

Publication date: Jun 15, 2025 Emerging evidence suggests that gastrointestinal dysfunction and enteric nervous system pathology play a critical role in the early stages of Parkinson’s disease. Considering the bidirectional ... Read more

March 22, 2025March 22, 2025

Regional difference on rotavirus vaccine coverage in children with diarrhea in Mozambique, before and during COVID-19 pandemic: a cross-sectional analysis.

Coronavirus Literature

Publication date: Mar 19, 2025 Immunization coverage is a global concern for the Immunization Agenda 2030 due to the Coronavirus disease (COVID-19) pandemic. Prior to the pandemic, Mozambique had a ... Read more

March 22, 2025March 22, 2025

Regional difference on rotavirus vaccine coverage in children with diarrhea in Mozambique, before and during COVID-19 pandemic: a cross-sectional analysis.

Coronavirus Literature

March 21, 2025March 21, 2025

Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression: a pragmatic, open-label, parallel-group, randomised controlled superiority trial in the UK.

Major Depressive Disorder Literature

Publication date: Apr 01, 2025 Lithium and quetiapine are first-line augmentation options for treatment-resistant depression; however, few studies have compared them directly, and none for longer than 8 weeks. We ... Read more

March 20, 2025March 20, 2025

Genomic characterisation of invasive Neisseria meningitidis in Spain (2011/12-2022/23): Expansion of clonal complex 213 and the potential threat to 4CMenB vaccine strain coverage.

Coronavirus Literature

Publication date: Mar 19, 2025 Invasive meningococcal disease (IMD) is associated with significant global morbidity and mortality and is addressed by conjugated polysaccharide and subcapsular vaccines. In Spain, data on ... Read more

March 20, 2025March 20, 2025

Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing.

Major Depressive Disorder Literature

Publication date: Mar 19, 2025 There is a vast prevalence of mental disorders, but patient responses to psychiatric medication fluctuate. As food choices and daily habits play a fundamental role ... Read more

March 19, 2025March 19, 2025

Reliability of Average Daily Steps Measured Through a Consumer Smartwatch in Parkinson Disease Phenotypes, Stages, and Severities: Cross-Sectional Study.

Parkinson's Disease Literature

Publication date: Mar 18, 2025 Average daily steps (avDS) could be a valuable indicator of real-world ambulation in people with Parkinson disease (PD), and previous studies have reported the validity ... Read more

March 17, 2025March 17, 2025

RAGE/AP-1/OTR signaling pathway in rat hippocampus DG involved in CUS induced depressive-like behaviors.

Major Depressive Disorder Literature

Publication date: Mar 14, 2025 There has been a growing body of evidence indicating that the oxytocin (OT) system plays a significant role in the neurophysiology of chronic stress-related mood ... Read more

March 16, 2025March 16, 2025

Childhood vaccination coverages in rural Guinea-Bissau before and during the early COVID-19 pandemic, a cohort study.

Coronavirus Literature

Publication date: Mar 12, 2025 The COVID-19 pandemic response diverted health systems resources to COVID-19 activities. Modelling studies and estimates based on administrative data indicate that the number of un- ... Read more

March 15, 2025March 15, 2025

Chronic DSS-Induced Colitis Exacerbates Parkinson’s Disease Phenotype and Its Pathological Features Following Intragastric Rotenone Exposure.

Parkinson's Disease Literature

Publication date: Feb 14, 2025 Background: Parkinson’s disease (PD) is intricately linked to gastrointestinal inflammation and the presence of neurotoxins in the gut, integrating α-syn pathologic alterations and subsequent neurodegeneration ... Read more