Search Results for: Release

January 8, 2025January 8, 2025

Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism.

Melanoma Literature

Publication date: Jan 01, 2025 Therapies against hematological malignancies using chimeric antigen receptors (CAR)-T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to ... Read more

December 29, 2024December 29, 2024

The Utility of Interferon-γ Release Assays in the Diagnosis of Tuberculosis in Patients With Cancer.

Tuberculosis Literature

Publication date: Dec 28, 2024 Patients with cancer are at elevated risk for tuberculosis (TB) reactivation. Diagnosis of latent TB infection and TB disease remains challenging in this patient population ... Read more

December 25, 2024December 25, 2024

Surface-Enhanced Raman Scattering Nanoendoscope for Quantification of a Protein Released under Physiological Stimulation in Brain Tissue.

Parkinson's Disease Literature

Publication date: Dec 24, 2024 A surface-enhanced Raman scattering (SERS) biosensor with minimal invasiveness and high spatial resolution has been developed as a nanoendoscope to detect changes in protein concentrations ... Read more

December 20, 2024December 20, 2024

The performance of a new rapid interferon gamma release assay based on fluorescence immunochromatography for Mycobacterium tuberculosis infection testing in village doctors in China.

Tuberculosis Literature

Publication date: Nov 08, 2024 The AIMTB rapid test assay is an emerging test, which adopted a fluorescence immunochromatographic assay to measure interferon-γ (IFN-γ) production following stimulation of effector memory ... Read more

December 20, 2024December 20, 2024

Low concordance between QIAreach QuantiFERON-TB, a novel interferon-gamma release assay, and QuantiFERON-TB Gold Plus, in a population-based survey in Blantyre, Malawi.

Tuberculosis Literature

Publication date: Dec 19, 2024 Urgent improvements in the diagnosis and management of Mycobacterium tuberculosis infection are required to reach End TB goals. Conventional interferon-gamma release assays (IGRAs), such as ... Read more

December 15, 2024December 15, 2024

Taurine, an essential amino acid, attenuates rotenone-induced Parkinson’s disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release.

Parkinson's Disease Literature

Publication date: Dec 12, 2024 Reducing antioxidant levels exacerbates the generation of reactive oxygen/nitrogen species, leading to alpha-synuclein aggregation and the degeneration of dopaminergic neurons. These play a key role ... Read more

December 13, 2024December 13, 2024

Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation.

Tuberculosis Literature

Publication date: Dec 11, 2024 Neutrophils are the most abundant cell type in the airways of tuberculosis patients. Mycobacterium tuberculosis (Mtb) infection induces the release of neutrophil extracellular traps (NETs); ... Read more

December 12, 2024December 12, 2024

Biomimetic Approach for Optimal Designing of the Shape and Controlled Release of Therapeutics from Tricompartmental Microcarriers for Managing Parkinson’s Disease.

Parkinson's Disease Literature

Publication date: Dec 11, 2024 Inspired by the intricate cellular morphology and the discoid shape of red blood cells (RBCs), biomimetic tricompartmental microcarriers (TCM) with controlled release profiles were engineered ... Read more

December 11, 2024December 11, 2024

A novel nature-inspired ligno-alginate hydrogel coated with FeO/GO for the efficient-sustained release of levodopa.

Parkinson's Disease Literature

Publication date: Dec 15, 2024 Levodopa (LD), a precursor to dopamine, is commonly used to treat Parkinson’s disease. However, its oral formulations suffer from low bioavailability, toxicity, and untargeted delivery. ... Read more

December 6, 2024December 6, 2024

Grip force release is impaired in parkinson’s disease during a force tracking task.

Parkinson's Disease Literature

Publication date: Dec 05, 2024 The controlled release of grasping forces underlies skilled dexterous interactions with objects. While declines in force generation and maintenance are well documented in people with ... Read more