Search Results for: Relevant neurodegenerative diseases

May 18, 2020May 18, 2020

Evidence for enhancer noncoding RNAs (enhancer-ncRNAs) with gene regulatory functions relevant to neurodevelopmental disorders

Publication date: May 16, 2020 Noncoding RNAs (ncRNAs) comprise a significant proportion of the mammalian genome, but their biological significance in neurodevelopment and in diseases is poorly understood. In this ... Read more

May 1, 2020May 1, 2020

New perspectives for selective NCX activators in neurodegenerative diseases.

Multiple Sclerosis Literature

Publication date: May 01, 2020 The Na/Ca exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate ... Read more

March 11, 2020March 11, 2020

Computational Tool Links Noncoding Sequences, Genes, and Psychiatric and Neurodegenerative Disorders

Major Depressive Disorder News

Publication date: Mar 11, 2020 Scientists headed by a team at the University of North Carolina (UNC) School of Medicine have developed a new computational tool called H-MAGMA that can ... Read more

March 11, 2020March 11, 2020

Computational Tool Links Noncoding Sequences, Genes, and Psychiatric and Neurodegenerative Disorders

Major Depressive Disorder News

Publication date: Mar 11, 2020 Scientists headed by a team at the University of North Carolina (UNC) School of Medicine have developed a new computational tool called H-MAGMA that can ... Read more

March 11, 2020March 11, 2020

Computational Tool Links Noncoding Sequences, Genes, and Psychiatric and Neurodegenerative Disorders

Major Depressive Disorder News

Publication date: Mar 11, 2020 Scientists headed by a team at the University of North Carolina (UNC) School of Medicine have developed a new computational tool called H-MAGMA that can ... Read more

July 11, 2020July 11, 2020

Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates.

Huntington's Disease Literature

Publication date: Jul 08, 2020 Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that ... Read more

July 7, 2020July 7, 2020

Differential effects of vagus nerve stimulation paradigms guide clinical development for Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jul 03, 2020 Vagus nerve stimulation (VNS) modifies brain rhythms in the locus coeruleus (LC) via the solitary nucleus. Degeneration of the LC in Parkinson’s disease (PD) is ... Read more

July 7, 2020July 7, 2020

Identification of unique and shared mitochondrial DNA mutations in neurodegeneration and cancer by single-cell mitochondrial DNA structural variation sequencing (MitoSV-seq).

Parkinson's Disease Literature

Publication date: Jul 03, 2020 Point mutations and structural variations (SVs) in mitochondrial DNA (mtDNA) contribute to many neurodegenerative diseases. Technical limitations and heteroplasmy, however, have impeded their identification, preventing ... Read more

July 2, 2020July 2, 2020

Patient and family social media use surrounding a novel treatment for a rare genetic disease: a qualitative interview study.

Precision Medicine Literature

Publication date: Jun 30, 2020 Advances in gene therapy and precision medicine have led to a growing number of novel treatments for rare genetic diseases. Patients/families may lack access to ... Read more

May 31, 2020May 31, 2020

Insulin-like growth factor 2 (IGF2) protects against Huntington’s disease through the extracellular disposal of protein aggregates

Huntington's Disease News

Publication date: May 31, 2020 Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that ... Read more