Search Results for: Signaling

January 18, 2025January 18, 2025

Integrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson’s disease.

Publication date: Jan 17, 2025 Parkinson’s disease (PD) is a chronic neurodegenerative disorder marked by dopaminergic neuron degeneration in the substantia nigra. Emerging evidence suggests vitamin D3 (VD) plays a ... Read more

January 11, 2025January 11, 2025

MicroRNA-204-5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats.

Major Depressive Disorder Literature

Publication date: Jan 10, 2025 Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural ... Read more

January 10, 2025January 10, 2025

Diclofenac Enhances the Response of BRAF Inhibitor to Melanoma Through ROS/p38/p53 Signaling.

Melanoma Literature

Publication date: Mar 01, 2025 BRAF inhibitors (BRAFi) represent a cornerstone in melanoma therapy due to their high efficacy. However, the emergence of resistance causes a significant challenge to their ... Read more

January 10, 2025January 10, 2025

Gestational stress disrupts dopamine and oxytocin signaling in the postpartum reward system of rats: implications for mood, motivation and mothering.

Major Depressive Disorder Literature

Publication date: Jan 09, 2025 Postpartum depression (PPD) affects up to 20% of new mothers and has adverse consequences for the well-being of both mother and child. Exposure to stress ... Read more

January 9, 2025January 9, 2025

Ras S89D mutation induced allosteric changes that promoted its nucleotide exchange and signaling activation.

Melanoma Literature

Publication date: Jan 06, 2025 The small GTPase Ras is among the most frequently mutated genes and its mutations often drive oncogenesis across various cancers. While the role of NRas ... Read more

January 7, 2025January 7, 2025

GPR88 impairs the signaling of kappa opioid receptors in a heterologous system and in primary striatal neurons.

Parkinson's Disease Literature

Publication date: Mar 01, 2025 The physiological role of GPR88, an orphan G protein-coupled receptor (GPCR) predominantly expressed in the striatum, remains unclear, despite its altered expression in parkinsonian animal ... Read more

January 7, 2025January 7, 2025

The potential ameliorative effect of mesenchymal stem cells-derived exosomes on cerebellar histopathology and their modifying role on PI3k-mTOR signaling in rat model of autism spectrum disorder.

Autism Literature

Publication date: Jan 06, 2025 Autism spectrum disorder (ASD) is a group of severe neurodevelopmental disorders. This study aimed to elucidate the potential ameliorating effect of postnatal administration of MSCs-derived ... Read more

January 5, 2025January 5, 2025

Type 2 Diabetes Mellitus Exacerbates Pathological Processes of Parkinson’s Disease: Insights from Signaling Pathways Mediated by Insulin Receptors.

Parkinson's Disease Literature

Publication date: Jan 04, 2025 Parkinson’s disease (PD), a chronic and common neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the dense part of the substantia ... Read more

January 4, 2025January 4, 2025

Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling.

Melanoma Literature

Publication date: Jan 07, 2025 Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA-cancer association, ... Read more

January 3, 2025January 3, 2025

Electroacupuncture Ameliorated Locomotor Symptoms in MPTP-Induced Mice Model of Parkinson’s Disease by Regulating Autophagy via Nrf2 Signaling.

Parkinson's Disease Literature

Publication date: Jan 02, 2025 Parkinson’s disease (PD) is a prevalent and challenging neurodegenerative disorder, and may involve impaired autophagy. Nuclear factor erythroid-2-related factor 2 (Nrf2) is crucial for regulating ... Read more