Search Results for: Small Molecule

January 5, 2020

Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils.

Melanoma Literature

Publication date: Jan 03, 2020 Phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine-nucleotide exchange factor that was originally discovered in neutrophils and is regulated by G ... Read more

December 10, 2019December 10, 2019

Geneticists identify small molecules that are potential indicators for disease

Huntington's Disease News

Publication date: Dec 10, 2019 New research from the Clemson Center for Human Genetics identified hundreds of metabolites that might serve as intermediates to translate variation in the genome to ... Read more

November 16, 2019November 16, 2019

Discovery of a potent small molecule inhibiting Huntington’s disease (HD) pathogenesis via targeting CAG repeats RNA and Poly Q protein.

Huntington's Disease Literature

Publication date: Nov 14, 2019 CAG repeats RNA causes various fatal neurodegenerative diseases exemplified by Huntington’s disease (HD) and several spinocerebellar ataxias (SCAs). Although there are differences in the pathogenic ... Read more

September 11, 2019September 11, 2019

New Small Molecule AZ67 May Help Prevent Brain Cell Death, Early Data Show

Huntington's Disease News

Publication date: Sep 10, 2019 This post was originally published on this site A small molecule that alters glucose metabolism in stressed brain cells may help prevent their death, representing ... Read more

August 24, 2019August 24, 2019

Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape.

Melanoma Literature

Publication date: Aug 22, 2019 Immunotherapy has led to a paradigm shift in the treatment of many advanced malignancies. Despite the success in treatment of tumors like non-small cell lung ... Read more

May 11, 2019May 11, 2019

Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington’s disease (HD) and spinocerebellar ataxia (SCAs).

Huntington's Disease Literature

Publication date: May 07, 2019 Huntington’s diseases (HD) is a very devastating disease caused by r(CAG) expansion in HTT gene, encoding the huntingtin protein. r(CAG) expansion causes disease via multiple ... Read more

May 11, 2019May 11, 2019

Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington’s disease (HD) and spinocerebellar ataxia (SCAs).

Huntington's Disease Literature

April 20, 2019April 20, 2019

Small Molecules with Big Promises for Curing Demyelinating Diseases.

Multiple Sclerosis Literature

Publication date: Apr 18, 2019 Myelin regeneration by myelinating oligodendrocytes is key to neuronal damage repair for treatment of neurological disorders such as multiple sclerosis. In this issue of Cell ... Read more

April 10, 2019

Small molecule targeting of RNA structures in neurological disorders.

Huntington's Disease Literature

Publication date: Apr 09, 2019 Aberrant RNA structure and function operate in neurological disease progression and severity. As RNA contributes to disease pathology in a complex fashion, that is, via ... Read more

March 17, 2019March 17, 2019

Small molecules as therapeutic drugs for Alzheimer’s disease.

Huntington's Disease Literature

Publication date: Mar 12, 2019 Mitochondrial dysfunction is a central protagonist of Alzheimer’s disease (AD) pathogenesis. Mitochondrial dysfunction stems from various factors including mitochondrial DNA damage and oxidative stress from ... Read more