Search Results for: Small Molecule

May 11, 2019May 11, 2019

Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington’s disease (HD) and spinocerebellar ataxia (SCAs).

Publication date: May 07, 2019 Huntington’s diseases (HD) is a very devastating disease caused by r(CAG) expansion in HTT gene, encoding the huntingtin protein. r(CAG) expansion causes disease via multiple ... Read more

May 11, 2019May 11, 2019

Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington’s disease (HD) and spinocerebellar ataxia (SCAs).

Huntington's Disease Literature

April 20, 2019April 20, 2019

Small Molecules with Big Promises for Curing Demyelinating Diseases.

Multiple Sclerosis Literature

Publication date: Apr 18, 2019 Myelin regeneration by myelinating oligodendrocytes is key to neuronal damage repair for treatment of neurological disorders such as multiple sclerosis. In this issue of Cell ... Read more

April 10, 2019

Small molecule targeting of RNA structures in neurological disorders.

Huntington's Disease Literature

Publication date: Apr 09, 2019 Aberrant RNA structure and function operate in neurological disease progression and severity. As RNA contributes to disease pathology in a complex fashion, that is, via ... Read more

March 17, 2019March 17, 2019

Small molecules as therapeutic drugs for Alzheimer’s disease.

Huntington's Disease Literature

Publication date: Mar 12, 2019 Mitochondrial dysfunction is a central protagonist of Alzheimer’s disease (AD) pathogenesis. Mitochondrial dysfunction stems from various factors including mitochondrial DNA damage and oxidative stress from ... Read more

March 17, 2019March 17, 2019

Small molecules as therapeutic drugs for Alzheimer’s disease.

Huntington's Disease Literature

February 17, 2019February 17, 2019

Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Melanoma Literature

Publication date: Feb 13, 2019 Inhibition of ubiquitin ligases with small molecule remains a very challenging task, given the lack of catalytic activity of the target and the requirement of ... Read more

February 16, 2019February 16, 2019

Small Molecule Docking of DNA Repair Proteins Associated with Cancer Survival Following PCNA Metagene Adjustment: A Potential Novel Class of Repair Inhibitors.

Melanoma Literature

Publication date: Feb 12, 2019 Natural and synthetic small molecules from the NCI Developmental Therapeutics Program (DTP) were employed in molecular dynamics-based docking with DNA repair proteins whose RNA-Seq based ... Read more

December 24, 2018December 24, 2018

A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75 Induces Melanoma Cell Death and Reduces Tumor Growth.

Melanoma Literature

Publication date: Dec 20, 2018 Small molecules offer powerful ways to alter protein function. However, most proteins in the human proteome lack small-molecule probes, including the large class of non-catalytic ... Read more

December 5, 2018December 5, 2018

Small Molecule Linked to Cells That Control Myelin Production and Repair in Study

Multiple Sclerosis News

Publication date: Dec 04, 2018 The formation of new myelin sheaths by oligodendrocytes is impaired in the absence of a small molecule, called Vav3, that oversees pathways regulating the shape ... Read more