Search Results for: Spinal Fluid

March 14, 2019March 14, 2019

Dynamic C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis.

Publication date: Mar 08, 2019 Cerebrospinal fluid (CSF) plays an important role in the clearance of solutes and maintenance of brain homeostasis. C-PiB PET was recently proposed as a tool ... Read more

March 13, 2019March 13, 2019

Alterations in the tyrosine and phenylalanine pathways revealed by biochemical profiling in cerebrospinal fluid of Huntington’s disease subjects.

Huntington's Disease Literature

Publication date: Mar 11, 2019 Huntington’s disease (HD) is a severe neurological disease leading to psychiatric symptoms, motor impairment and cognitive decline. The disease is caused by a CAG expansion ... Read more

March 13, 2019March 13, 2019

Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study.

Multiple Sclerosis Literature

Publication date: Mar 11, 2019 Long-term outcome in multiple sclerosis (MS) depends on early treatment. In patients with acute optic neuritis (ON), an early inflammatory event, we investigated markers in ... Read more

March 5, 2019March 5, 2019

#ACTRIMS2019 – Cerebrospinal Fluid, Meninges Inflammation Profile Can Stratify MS Patients

Multiple Sclerosis News

Publication date: Mar 04, 2019 Recent studies suggested that extensive grey matter damage and more rapid disease progression were tied to high levels of inflammation in the meninges – the ... Read more

February 13, 2019February 13, 2019

Longitudinally persistent cerebrospinal fluid B-cells can resist treatment in multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Feb 12, 2019 B-cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS). Clonally related B-cells exist in the cerebrospinal fluid (CSF), meninges, and central nervous ... Read more

February 6, 2019February 6, 2019

Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections.

Multiple Sclerosis Literature

Publication date: Feb 05, 2019 The tryptophan-kynurenine-NAD+ pathway is closely associated with regulation of immune cells toward less inflammatory phenotypes and may exert neuroprotective effects. Investigating its regulation in CNS ... Read more

February 3, 2019February 3, 2019

High performance of cerebrospinal fluid immunoglobulin G analysis for diagnosis of multiple sclerosis.

Multiple Sclerosis Literature

Publication date: Feb 01, 2019 The 2017 revision of the McDonald criteria highlights the usefulness of cerebrospinal fluid (CSF) immunoglobulin G (IgG) analysis to diagnose multiple sclerosis (MS). The objective ... Read more

January 30, 2019January 30, 2019

Cerebrospinal fluid flow dynamics in Huntington’s disease evaluated by phase contrast MRI.

Huntington's Disease Literature

Publication date: Jan 28, 2019 Multiple targeted therapeutics for Huntington’s disease are now in clinical trials, including intrathecally-delivered compounds. Previous research suggests CSF dynamics may be altered in Huntington’s disease, ... Read more

January 28, 2019January 28, 2019

Biochemical Differences in Cerebrospinal Fluid between Secondary Progressive and Relapsing⁻Remitting Multiple Sclerosis.

Multiple Sclerosis Literature

Publication date: Jan 24, 2019 To better understand the pathophysiological differences between secondary progressive multiple sclerosis (SPMS) and relapsing-remitting multiple sclerosis (RRMS), and to identify potential biomarkers of disease progression, ... Read more

January 24, 2019January 24, 2019

Development and validation of an advanced fragment analysis-based assay for the detection of 22 pathogens in the cerebrospinal fluid of patients with meningitis and encephalitis.

Tuberculosis Literature

Publication date: Jan 21, 2019 Meningitis and encephalitis (ME) are central nervous system (CNS) infections mainly caused by bacteria, mycobacteria, fungi, viruses, and parasites that result in high morbidity and ... Read more