Search Results for: Target

October 14, 2024October 14, 2024

TarKG: A Comprehensive Biomedical Knowledge Graph for Target Discovery.

Dr. Richard A. Blevins Literature, Informatics Literature

Publication date: Oct 11, 2024 Target discovery is a crucial step in drug development, as it directly affects the success rate of clinical trials. Knowledge graphs (KGs) offer unique advantages ... Read more

October 13, 2024October 13, 2024

Targeted inhibition of the IL5 axis for immune checkpoint inhibitors eosinophilic-induced adverse events.

Melanoma Literature

Publication date: Oct 12, 2024 Given the broad implementation of immune checkpoint inhibitors (ICI) for cancer therapy, we encounter a variety of immune-related adverse events (irAE) including immune-related blood eosinophilia. ... Read more

October 13, 2024October 13, 2024

Development of Non-Viral Targeted RNA Delivery Vehicles – A Key Factor in Success of Therapeutic RNA.

Coronavirus Literature

Publication date: Oct 11, 2024 Decade-long efforts in medicinal biotechnology have enabled large-scale in-vitro production of optimized therapeutic RNA constructs for stable in-vivo delivery and modify the expression of disease-related ... Read more

October 13, 2024October 13, 2024

Development of Non-Viral Targeted RNA Delivery Vehicles – A Key Factor in Success of Therapeutic RNA.

Coronavirus Literature

October 13, 2024October 13, 2024

Development of Non-Viral Targeted RNA Delivery Vehicles – A Key Factor in Success of Therapeutic RNA.

Coronavirus Literature

October 13, 2024October 13, 2024

Development of Non-Viral Targeted RNA Delivery Vehicles – A Key Factor in Success of Therapeutic RNA.

Coronavirus Literature

October 12, 2024October 12, 2024

Identification of targetable epigenetic vulnerabilities in uveal melanoma

Melanoma News

Publication date: Oct 10, 2024 Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, which preferentially metastasizes to the liver in approximately half of all cases. Metastatic ... Read more

October 12, 2024October 12, 2024

Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model.

Melanoma Literature

Publication date: Oct 10, 2024 mRNA-based applications have achieved remarkable success in the development of next-generation vaccines and the treatment of diverse liver diseases. Overcoming the challenge of delivering mRNA ... Read more

October 12, 2024October 12, 2024

Simplified Lipid Nanoparticles for Tissue- And Cell-Targeted mRNA Delivery Facilitate Precision Tumor Therapy in a Lung Metastasis Mouse Model.

Melanoma Literature

October 12, 2024October 12, 2024

Identification of novel broad-spectrum antiviral drugs targeting the N-terminal domain of the FIPV nucleocapsid protein.

Coronavirus Literature

Publication date: Nov 01, 2024 Coronaviruses pose serious threats to human and animal health worldwide, of which their structural nucleocapsid (N) proteins play multiple key roles in viral replication. However, ... Read more