Search Results for: Thes

January 17, 2020

In Silico design of AVP (4-5) peptide and synthesis, characterization and in vitro activity of chitosan nanoparticles.

Publication date: Jan 16, 2020 Arginine-vasopressin (AVP) is a neuropeptide and provides learning and memory modulation. The AVP (4-5) dipeptide corresponds to the N-terminal fragment of the major vasopressin metabolite ... Read more

January 15, 2020January 15, 2020

Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme.

Melanoma Literature

Publication date: Jan 15, 2020 Autotaxin (ATX), a glycoprotein (~125 kDa) isolated as an autocrine motility factor from melanoma cells, belongs to a seven-membered family of ectonucleotide pyrophosphatase/phosphodiesterase (ENPP), and ... Read more

January 7, 2020January 7, 2020

Advances in regional anaesthesia and acute pain management: a narrative review.

Opioids Literature

Publication date: Jan 01, 2020 Regional anaesthesia has undergone several exciting advances in the past few decades. Ultrasound-guided techniques of peripheral nerve blockade have become the gold standard thanks to ... Read more

January 5, 2020January 5, 2020

Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies.

Melanoma Literature

Publication date: Jan 03, 2020 Cancer is one of the leading causes of death worldwide and requires intense and growing research investments from the public and private sectors. This is ... Read more

January 5, 2020January 5, 2020

The Benefits of Opioid Free Anesthesia and the Precautions Necessary When Employing It.

Opioids Literature

Publication date: Nov 13, 2019 The use of opioids in the perioperative period is associated with respiratory depression, impaired gastrointestinal function, post-operative nausea and vomiting (PONV), pruritus, urinary retention, delirium ... Read more

January 1, 2020

Zinc oxide nanoparticles synthesized from Cardiospermum halicacabum and its anticancer activity in human melanoma cells (A375) through the modulation of apoptosis pathway.

Melanoma Literature

Publication date: Jan 01, 2020 Metallic nanoparticles were extensively examined to explore their impending exploitations over pharmaceutical purposes. Current work attempting to explores the cytotoxic capacity of zinc oxide (ZnO) ... Read more

December 18, 2019

Tramadol-associated hallucinations: a systematic review and narrative synthesis of their pathophysiology, diagnosis, and treatment.

Opioids Literature

Publication date: Dec 16, 2019 Recent prescribing trends reflect government-led efforts undertaken in both the U.S. and Canada to decrease opioid use. These provisions reflect a reduction in the use ... Read more

December 15, 2019

Synthesis and evaluation of 1,3,5-triazine derivatives as sunscreens useful to prevent skin cancer.

Melanoma Literature

Publication date: Dec 15, 2019 The incidence of skin cancers such as non-melanoma skin cancer and malignant melanoma has increased in the last few years mainly because of chronic exposure ... Read more

December 8, 2019December 8, 2019

Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP-1 Activity and Melanin Biosynthesis in Cultured Skin Cells.

Melanoma Literature

Publication date: Dec 07, 2019 The regulation of mitochondrial biogenesis, melanogenesis, and connective tissue proteins is critical for homeostasis and aging skin cells. We examined the biological effects of polydeoxyribonucleotide ... Read more

December 1, 2019December 1, 2019

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives.

Melanoma Literature

Publication date: Dec 01, 2019 Two new series of heterocyclic derivatives with potential anticancer activity, in which a pyrrolopyridazine or a pyrrolophthalazine moiety was introduced in place of the 3′-hydroxy-4′-methoxyphenyl ... Read more