Search Results for: Thes

March 24, 2020March 24, 2020

Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders.

Publication date: Mar 23, 2020 Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here ... Read more

March 23, 2020

Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-a] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process.

Melanoma Literature

Publication date: Mar 17, 2020 Cancer is a leading cause of human death worldwide. One of the greatest challenges in cancer therapy is the discovery and design of novel products ... Read more

March 20, 2020March 20, 2020

Salivary cortisol levels and anxiety in melanoma patients undergoing sentinel lymph node excision under local anesthesia versus general anesthesia: a prospective study.

Melanoma Literature

Publication date: Mar 10, 2020 Sentinel lymph node excision (SLNE) can be performed in tumescent local anesthesia (TLA) or general anesthesia (GA). Perioperative cortisol level changes and anxiety are common ... Read more

March 20, 2020March 20, 2020

Synthesis, Characterization, Cytotoxic Activity, and Metabolic Studies of Ruthenium(II) Polypyridyl Complexes Containing Flavonoid Ligands.

Melanoma Literature

Publication date: Mar 19, 2020 Four novel monocationic Ru(II) polypyridyl complexes were synthesized with the general formula X, where DIP is 4,7-diphenyl-1,10-phenanthroline, flv stands for the flavonoid ligand (5-hydroxyflavone in ... Read more

March 15, 2020

Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies.

Melanoma Literature

Publication date: Mar 15, 2020 A series of novel triptolide/furoxans hybrids were designed and synthesized as analogues of triptolide, which is a naturally derived compound isolated from the thunder god ... Read more

March 14, 2020March 14, 2020

Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase.

Melanoma Literature

Publication date: Mar 12, 2020 Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of non-ribosomal peptide synthetase (NRPS) and polyketide ... Read more

March 14, 2020March 14, 2020

Anonymization through Data Synthesis using Generative Adversarial Networks (ADS-GAN).

Precision Medicine Literature

Publication date: Mar 12, 2020 The medical and machine learning communities are relying on the promise of artificial intelligence (AI) to transform medicine through enabling more accurate decisions and personalized ... Read more

March 13, 2020March 13, 2020

These Two Brain Networks Aren’t Active at the Same Time-but They’re Both Key to Consciousness

Major Depressive Disorder News

Publication date: Mar 13, 2020 One of the most recent studies showed a clear relationship between two brain networks critical to consciousness. In a paper published this week in Science ... Read more

March 13, 2020March 13, 2020

These Two Brain Networks Aren’t Active at the Same Time-but They’re Both Key to Consciousness

Major Depressive Disorder News

Publication date: Mar 13, 2020 One of the most recent studies showed a clear relationship between two brain networks critical to consciousness. In a paper published this week in Science ... Read more

March 3, 2020March 3, 2020

Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma.

Melanoma Literature

Publication date: Feb 28, 2020 Melanocytic tumors with inactivation of protein kinase A regulatory subunit-? (PRKAR1A) have large oval nuclei and intense pigmentation. Historically, these tumors have been categorized under ... Read more