Search Results for: Tunicamycin

September 6, 2024September 6, 2024

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19.

Publication date: Sep 06, 2024 Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a ... Read more

August 14, 2024August 14, 2024

Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor properties.

Melanoma Literature

Publication date: Aug 13, 2024 Computational pharmacogenomics can potentially identify new indications for already approved drugs and pinpoint compounds with similar mechanism-of-action. Here, we used an integrated drug repositioning approach ... Read more

August 14, 2024August 14, 2024

Integrated transcriptomics- and structure-based drug repositioning identifies drugs with proteasome inhibitor properties.

Melanoma Literature

July 18, 2024July 18, 2024

Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson’s disease.

Parkinson's Disease Literature

Publication date: Jul 17, 2024 Cerebral dopamine neurotrophic factor (CDNF) and its close structural relative, mesencephalic astrocyte-derived neurotrophic factor (MANF), are proteins with neurotrophic properties. CDNF protects and restores the ... Read more