Search Results for: Viral

January 18, 2025January 18, 2025

Defining the Critical Requisites for Accurate Simulation of SARS-CoV-2 Viral Dynamics: Patient Characteristics and Data Collection Protocol.

Publication date: Jan 01, 2025 Mathematical models of viral dynamics are crucial in understanding infection trajectories. However, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load data often includes limited ... Read more

January 18, 2025January 18, 2025

In-silico screening and analysis of missense SNPs in human CYP3A4/5 affecting drug-enzyme interactions of FDA-approved COVID-19 antiviral drugs.

Coronavirus Literature

Publication date: Jan 16, 2025 Single nucleotide polymorphisms (SNPs) represent the prevailing form of genetic variations observed in the human population. Such variations could alter the encoded enzymes’ activities. CYP3A4/5 ... Read more

January 18, 2025January 18, 2025

Shortened SARS-CoV-2 viral RNA shedding in saliva during early Omicron compared to wild-type pandemic phase.

Coronavirus Literature

Publication date: Jan 17, 2025 This study compared the dynamics of SARS-CoV-2 viral shedding in saliva between wild-type virus-infected and Omicron-infected household cohorts. Pre-existing immunity in participants likely shortens the ... Read more

January 18, 2025January 18, 2025

Longitudinal host transcriptional responses to SARS-CoV-2 infection in adults with extremely high viral load.

Coronavirus Literature

Publication date: Jan 17, 2025 Current understanding of viral dynamics of SARS-CoV-2 and host responses driving the pathogenic mechanisms in COVID-19 is rapidly evolving. Here, we conducted a longitudinal study ... Read more

January 18, 2025January 18, 2025

A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential.

Chikungunya Literature

Publication date: Jan 16, 2025 The SARS-CoV-2 pandemic has highlighted the need for society, as a whole, to be prepared against potential pandemics caused by a variety of different viral ... Read more

January 17, 2025January 17, 2025

Systematic Molecular Influenza A/B Screening Upon Hospital Admission in Belgium, January-April 2022: Positivity Ratios and Viral Loads According to Symptomatology, Age, and Vaccination Status.

Coronavirus Literature

Publication date: Jan 01, 2025 Three hospitals implemented molecular point-of-care tests (POCTs) to screen patients for SARS-CoV-2 infection upon admission during the 2021/2022 influenza season, which in Belgium lasted from ... Read more

January 17, 2025January 17, 2025

Revisiting the potential of natural antimicrobial peptides against emerging respiratory viral disease: a review.

Coronavirus Literature

Publication date: Feb 01, 2025 This review assesses the antiviral capabilities of antimicrobial peptides (AMPs) against SARS-CoV-2 and other respiratory viruses, focussing on their therapeutic potential. AMPs, derived from natural ... Read more

January 16, 2025January 16, 2025

Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity.

Coronavirus Literature

Publication date: Jan 15, 2025 The main protease (M) of SARS-CoV-2 is a key drug target for the development of antiviral therapeutics. Here, we designed and synthesized a series of ... Read more

January 16, 2025January 16, 2025

Subacute thyroiditis – Is it really linked to viral infection? Retrospective hospital patient registry study.

Coronavirus Literature

Publication date: Jan 15, 2025 Subacute thyroiditis (SAT) is a painful inflammatory disorder of the thyroid gland, which – after a phase of thyrotoxicosis – leads to transient, or less ... Read more

January 16, 2025January 16, 2025

Rapid and comprehensive detection of viral antibodies and nucleic acids via an acoustofluidic integrated molecular diagnostics chip: AIMDx.

Coronavirus Literature

Publication date: Jan 17, 2025 Precise and rapid disease detection is critical for controlling infectious diseases like COVID-19. Current technologies struggle to simultaneously identify viral RNAs and host immune antibodies ... Read more