Search Results for: Viral replication

June 12, 2025

Identification of CASC3 as a novel SADS-CoV restriction factor through liquid-liquid phase separation inhibiting viral replication.

Publication date: Jul 01, 2025 Swine acute diarrhoea syndrome coronavirus (SADS-CoV) is a newly emerging highly pathogenic virus that likely originated from the closely related HKU2 bat coronaviruses. The cross-species ... Read more

May 24, 2025May 24, 2025

HERC5-mediated ISGylation of SARS-CoV-2 nsp8 facilitates its degradation and inhibits viral replication.

Coronavirus Literature

Publication date: May 21, 2025 Severe acute respiratory syndrome coronavirus 2 non-structural protein 8 (SARS-CoV-2 nsp8) is a multifunctional protein essential for viral replication and immune evasion. However, the host ... Read more

May 17, 2025

TGEV NSP1 enhances viral replication through antagonizing stress granule formation.

Coronavirus Literature

Publication date: Jun 01, 2025 Stress granules (SGs) are membrane-less organelles that form in response to adverse external stimuli. Upon viral invasion, SGs formation can serve as a cellular defence ... Read more

May 31, 2025

Exploring suramin’s antiviral effects: targeting Lymphocytic Choriomeningitis virus cell entry and replication/transcription processes.

Coronavirus Literature

Publication date: Aug 01, 2025 The Arenavirus family comprises of multiple pathogenic human viruses. Currently, there are no licensed vaccines or antiviral agents against arenavirus infections; therefore, there is a ... Read more

May 29, 2025

Hypericin Suppresses SARS-CoV-2 Replication and Synergizes with Antivirals via Dual Targeting of RdRp and 3CLpro.

Coronavirus Literature

Publication date: Apr 27, 2025 The continuous emergence of SARS-CoV-2 variants underscores the need for novel antiviral candidates. Hypericin (HY), a compound derived from Hypericum perforatum, exhibited potent in vitro ... Read more

May 6, 2025

Replication Features of SARS-CoV-2 and Advantages of Targeting S Protein with Aptamers to Block Viral Entry.

Coronavirus Literature

Publication date: Apr 29, 2025 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus of the coronaviridae family. The virus enters the cell through binding to the corresponding receptor ... Read more

June 12, 2025

Swine interferon-induced transmembrane proteins inhibit porcine epidemic diarrhea virus replication.

Coronavirus Literature

Publication date: Jul 01, 2025 Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) has significantly harmed the global pig industry economically. Interferons can induce the expression of ... Read more

June 11, 2025June 11, 2025

Carboxymethyl-starch:iodine complexes as virucidal agents: salivary amylase triggers on-site iodine release, preventing human coronavirus OC43 replication.

Coronavirus Literature

Publication date: Jun 08, 2025 Coronavirus disease 19 (COVID-19), caused by the highly transmissible and pathogenic SARS-CoV-2 virus, has led the global pandemia. While various vaccines have been developed, drugs ... Read more

June 11, 2025

Viral evolution prediction identifies broadly neutralizing antibodies to existing and prospective SARS-CoV-2 variants.

Coronavirus Literature

Publication date: Jun 10, 2025 Monoclonal antibodies (mAbs) targeting the SARS-CoV-2 receptor-binding domain are used to treat and prevent COVID-19. However, the rapid evolution of SARS-CoV-2 drives continuous escape from ... Read more

June 9, 2025June 9, 2025

Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication.

Coronavirus Literature

Publication date: May 29, 2025 The protein casein kinase 2 (CK2) has been shown to be upregulated in SARS-CoV-2 infections. However, few inhibitors have been tested for antiviral activity against ... Read more