Search Results for: Virus

February 20, 2020February 20, 2020

ViroPanel: Hybrid capture and massively parallel sequencing for simultaneous detection and profiling of oncogenic virus infection and tumor genome.

Publication date: Feb 14, 2020 Precision cancer medicine aims to classify tumors by site, histology, and molecular testing to determine an “individualized” profile of cancer alterations. Viruses are a major ... Read more

February 16, 2020

MDA5 against enteric viruses through induction of interferon-like response partially via the JAK-STAT cascade.

Melanoma Literature

Publication date: Feb 10, 2020 Enteric viruses including hepatitis E virus (HEV), human norovirus (HuNV), and rotavirus are causing global health issues. The host interferon (IFN) response constitutes the first-line ... Read more

February 9, 2020February 9, 2020

The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus.

Melanoma Literature

Publication date: Feb 04, 2020 Oncolytic viruses, including live attenuated measles virus (MV) vaccine strains, have recently been shown as promising therapeutic agents against human malignancies. In this study, the ... Read more

February 6, 2020

Specific antibodies reacting to JC polyomavirus capsid protein mimotopes in sera from multiple sclerosis and other neurological diseases-affected patients.

Multiple Sclerosis Literature

Publication date: Feb 03, 2020 Published data support the hypothesis that viruses could be trigger agents of multiple sclerosis onset. This link is based on evidence of early exposure to ... Read more

January 1, 2020

Design and Production of Newcastle Disease Virus for Intratumoral Immunomodulation.

Melanoma Literature

Publication date: Sep 06, 2019 Newcastle disease virus (NDV) is an avian paramyxovirus that has been extensively studied as an oncolytic agent, in addition to being an economically important pathogen ... Read more

January 1, 2020January 1, 2020

Generating Primary Models of Human Cancer to Aid in the Development of Clinically Relevant Oncolytic Viruses.

Precision Medicine Literature

Publication date: Sep 06, 2019 Oncolytic viruses (OVs) represent a rapidly advancing class of cancer immunotherapeutic that is helping to shift the treatment paradigm of cancer. Initially thought to only ... Read more

December 25, 2019December 25, 2019

Design and application of oncolytic viruses for cancer immunotherapy.

Melanoma Literature

Publication date: Dec 21, 2019 The approval of the first oncolytic virus (OV) for the treatment of metastatic melanoma and the recent discovery that the use of oncolytic viruses may ... Read more

December 20, 2019December 20, 2019

Enhanced Therapeutic Efficacy of a Novel Oncolytic Herpes Simplex Virus Type 2 Encoding an Antibody Against Programmed Cell Death 1.

Melanoma Literature

Publication date: Dec 20, 2019 The efficacy of immune checkpoint blockade therapy against immunologically “cold” tumors can be enhanced by applying the checkpoint inhibitors in combination with oncolytic viruses. Alternatively, ... Read more

December 20, 2019

Engineering Requirements of a Herpes Simplex Virus Patient Registry: Discovery Phase of a Real-World Evidence Platform to Advance Pharmacogenomics and Personalized Medicine.

Precision Medicine Literature

Publication date: Dec 15, 2019 Comprehensive pharmacogenomic understanding requires both robust genomic and demographic data. Patient registries present an opportunity to collect large amounts of robust, patient-level data. Pharmacogenomic advancement ... Read more

December 20, 2019

Engineering Requirements of a Herpes Simplex Virus Patient Registry: Discovery Phase of a Real-World Evidence Platform to Advance Pharmacogenomics and Personalized Medicine.

Precision Medicine Literature