Search Results for: Virus

September 19, 2019September 19, 2019

Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation.

Publication date: Sep 17, 2018 Neuroinvasive infections with mosquito-borne alphaviruses such as Western equine encephalitis virus (WEEV) can cause post-encephalitic parkinsonism. To understand the mechanisms underlying these neurological effects, we ... Read more

September 14, 2019September 14, 2019

#ECTRIMS2019 – Human Herpesvirus 6A May Increase MS Risk, Study Suggests

Multiple Sclerosis News

Publication date: Sep 13, 2019 In contrast, the IgG response against IE1B did not correlate with such risk in patients with established MS. -The A variant came out as extremely ... Read more

September 10, 2019September 10, 2019

Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-Like Particles.

Melanoma Literature

Publication date: Sep 09, 2019 Mucin-1 (MUC1) is a highly attractive antigenic target for anti-cancer vaccines. Naturally existing MUC1 can contain multiple types of O-linked glycans, including the Thomsen-Friedenreich (Tf) ... Read more

September 2, 2019September 2, 2019

Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance.

Melanoma Literature

Publication date: Aug 27, 2019 Immunotherapy can reinvigorate dormant responses to cancer, but response rates remain low. Oncolytic viruses, which replicate in cancer cells, induce tumor lysis and immune priming, ... Read more

September 1, 2019September 1, 2019

Adeno-associated virus-based Alzheimer’s disease mouse models and potential new therapeutic avenues.

Precision Medicine Literature

Publication date: Sep 01, 2019 Alzheimer’s disease (AD) is a highly prevalent neurodegenerative condition that presents with cognitive decline. The current understanding of underlying disease mechanisms remains incomplete. Genetically modified ... Read more

August 29, 2019August 29, 2019

Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.

Melanoma Literature

Publication date: Aug 27, 2019 Intratumoral injection of oncolytic adenovirus Delta-24-RGDOX induces efficacious anti-glioma immunity in syngeneic glioma mouse models. We hypothesized that localized treatment with the virus is effective ... Read more

August 29, 2019

Increased serological response against human herpesvirus 6A is associated with risk for multiple sclerosis

Multiple Sclerosis News

Publication date: Aug 29, 2019 Human herpesvirus (HHV)-6A or HHV-6B involvement in multiple sclerosis (MS) etiology has remained controversial mainly due to the lack of serological methods that can distinguish ... Read more

August 16, 2019August 16, 2019

STAT3 Contributes To Oncolytic Newcastle Disease Virus-Induced Immunogenic Cell Death in Melanoma Cells.

Melanoma Literature

Publication date: Jan 29, 2019 Background: Oncolytic viruses (OVs) are emerging as potent inducers of immunogenic cell death (ICD), releasing danger-associated molecular patterns (DAMPs) that induce potent anticancer immunity. Oncolytic ... Read more

August 16, 2019August 16, 2019

Oncolytic virus immunotherapy induces immunogenic cell death and overcomes STING deficiency in melanoma.

Melanoma Literature

Publication date: Jan 24, 2019 Successful immunotherapy for melanoma depends on the recruitment of effector CD8 T cells to the tumor microenvironment. Factors contributing to T cell regulation in melanoma ... Read more

August 15, 2019August 15, 2019

Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma.

Melanoma Literature

Publication date: Aug 10, 2019 Talimogene laherparepvec (T-VEC) is an intralesionally delivered, modified herpes simplex virus type-1 oncolytic immunotherapy. The biodistribution, shedding, and potential transmission of T-VEC was systematically evaluated ... Read more